Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support
By unloading the failing heart, left ventricular (LV) assist devices (LVADs) provide a favorable environment for reversing adverse structural and functional cardiac changes. Prior reports have suggested that an improved native LV function might contribute to the development of LVAD thrombosis. We us...
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| Veröffentlicht in: | The Journal of heart and lung transplantation 2023-07, Vol.42 (7), p.853-858 |
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| container_title | The Journal of heart and lung transplantation |
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| creator | Kyriakopoulos, Christos P. Horne, Benjamin D. Sideris, Konstantinos Taleb, Iosif Griffin, Rachel J. Sheffield, Eric Alharethi, Rami Hanff, Thomas C. Stehlik, Josef Selzman, Craig H. Drakos, Stavros G. |
| description | By unloading the failing heart, left ventricular (LV) assist devices (LVADs) provide a favorable environment for reversing adverse structural and functional cardiac changes. Prior reports have suggested that an improved native LV function might contribute to the development of LVAD thrombosis. We used the Interagency Registry for Mechanically Assisted Circulatory Support and found that LV functional improvement is associated with a lower risk for device thrombosis. The risk for cerebrovascular accident and transient ischemic attack was comparable across post-LVAD LV function subgroups, while the risk of hemolysis was lower in subgroups of patients with better LV function on LVAD support. |
| doi_str_mv | 10.1016/j.healun.2023.03.004 |
| format | Article |
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Prior reports have suggested that an improved native LV function might contribute to the development of LVAD thrombosis. We used the Interagency Registry for Mechanically Assisted Circulatory Support and found that LV functional improvement is associated with a lower risk for device thrombosis. The risk for cerebrovascular accident and transient ischemic attack was comparable across post-LVAD LV function subgroups, while the risk of hemolysis was lower in subgroups of patients with better LV function on LVAD support.</description><identifier>ISSN: 1053-2498</identifier><identifier>ISSN: 1557-3117</identifier><identifier>EISSN: 1557-3117</identifier><identifier>DOI: 10.1016/j.healun.2023.03.004</identifier><identifier>PMID: 37086251</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>device thrombosis ; Heart ; heart assist device ; Heart Failure ; Heart Ventricles ; Heart-Assist Devices - adverse effects ; Humans ; left ventricular assist device ; myocardial recovery ; Thrombosis - etiology ; Ventricular Function, Left</subject><ispartof>The Journal of heart and lung transplantation, 2023-07, Vol.42 (7), p.853-858</ispartof><rights>2023 International Society for Heart and Lung Transplantation</rights><rights>Copyright © 2023 International Society for Heart and Lung Transplantation. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-9a346490ea5668dfe5cf179db926b168eb0b1f6c34ff1d31127814a0f0f3316d3</citedby><cites>FETCH-LOGICAL-c464t-9a346490ea5668dfe5cf179db926b168eb0b1f6c34ff1d31127814a0f0f3316d3</cites><orcidid>0000-0002-4271-6619 ; 0000-0002-1223-327X ; 0000-0002-0029-5019 ; 0000-0002-4596-3877 ; 0000-0002-7362-0513 ; 0000-0001-9415-1245 ; 0000-0002-2656-0263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.healun.2023.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37086251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kyriakopoulos, Christos P.</creatorcontrib><creatorcontrib>Horne, Benjamin D.</creatorcontrib><creatorcontrib>Sideris, Konstantinos</creatorcontrib><creatorcontrib>Taleb, Iosif</creatorcontrib><creatorcontrib>Griffin, Rachel J.</creatorcontrib><creatorcontrib>Sheffield, Eric</creatorcontrib><creatorcontrib>Alharethi, Rami</creatorcontrib><creatorcontrib>Hanff, Thomas C.</creatorcontrib><creatorcontrib>Stehlik, Josef</creatorcontrib><creatorcontrib>Selzman, Craig H.</creatorcontrib><creatorcontrib>Drakos, Stavros G.</creatorcontrib><title>Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support</title><title>The Journal of heart and lung transplantation</title><addtitle>J Heart Lung Transplant</addtitle><description>By unloading the failing heart, left ventricular (LV) assist devices (LVADs) provide a favorable environment for reversing adverse structural and functional cardiac changes. 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| ispartof | The Journal of heart and lung transplantation, 2023-07, Vol.42 (7), p.853-858 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | device thrombosis Heart heart assist device Heart Failure Heart Ventricles Heart-Assist Devices - adverse effects Humans left ventricular assist device myocardial recovery Thrombosis - etiology Ventricular Function, Left |
| title | Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support |
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