Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist

We have recently reported on the use of aryl-fluorosulfates in designing water- and plasma-stable agents that covalently target Lys, Tyr, or His residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. Here, we report further structural, cellular, and pharmacological chara...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-06, Vol.66 (12), p.8159-8169
Hauptverfasser:	Udompholkul, Parima, Garza-Granados, Ana, Alboreggia, Giulia, Baggio, Carlo, McGuire, Jack, Pegan, Scott D., Pellecchia, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Inhibitor of Apoptosis Proteins Pharmacology & Pharmacy Protein Binding X-Linked Inhibitor of Apoptosis Protein - metabolism
Online-Zugang:	Volltext
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