Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke

The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2023-07, Vol.43 (7), p.1099-1114
Hauptverfasser:	Loppi, Sanna H, Tavera-Garcia, Marco A, Becktel, Danielle A, Maiyo, Boaz K, Johnson, Kristos E, Nguyen, Thuy-Vi V, Schnellmann, Rick G, Doyle, Kristian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fatty Acids - metabolism Glycolysis Male Mice Microglia - metabolism Original Stroke - metabolism White Matter - metabolism
Online-Zugang:	Volltext
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