Wnt signaling preserves progenitor cell multipotency during adipose tissue development

Mesenchymal stem/progenitor cells are essential for tissue development and repair throughout life, but how they are maintained under chronic differentiation pressure is not known. Using single-cell transcriptomics of human progenitor cells we find that adipose differentiation stimuli elicit two cell...

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Veröffentlicht in:	Nature metabolism 2023-06, Vol.5 (6), p.1014-1028
Hauptverfasser:	Yang Loureiro, Zinger, Joyce, Shannon, DeSouza, Tiffany, Solivan-Rivera, Javier, Desai, Anand, Skritakis, Pantos, Yang, Qin, Ziegler, Rachel, Zhong, Denise, Nguyen, Tammy T., MacDougald, Ormond A., Corvera, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/443/319/2723 692/4017 Adipocytes - metabolism Adipogenesis Adipose Tissue Animals Biomedical and Life Sciences Humans Life Sciences Mice Stem Cells Wnt Signaling Pathway
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