Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition

[Display omitted] BMS906024, a γ-secretase inhibitor that blocks Notch signaling, was previously shown to inhibit Cryptosporidium parvum growth in vitro. A structure–activity relationship (SAR) analysis of BMS906024 reported herein demonstrates the importance of the stereochemistry of the C-3 benzod...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-06, Vol.90, p.129328-129328, Article 129328
Hauptverfasser:	Lee, Seungheon, Love, Melissa S., Modukuri, Ramkumar, Chatterjee, Arnab K., Huerta, Lauren, Lawson, Ann P., McNamara, Case W., Mead, Jan R., Hedstrom, Lizbeth, Cuny, Gregory D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cryptosporidiosis Cryptosporidium Cryptosporidium parvum Humans Structure-Activity Relationship
Online-Zugang:	Volltext
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