Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam
•Regular heroin injection could be protective for depression and psychotic symptoms.•Psychiatric burden of methamphetamine use is high.•PWID treated with methadone are less often depressed.•Regular polysubstance use is associated with higher rate of psychiatric disorders. Psychiatric comorbidities a...
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| Veröffentlicht in: | Drug and alcohol dependence 2020-11, Vol.216, p.108334-108334, Article 108334 |
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| creator | Le, Sao Mai Trouiller, Philippe Duong Thi, Huong Khuat Thi Hai, Oanh Pham Minh, Khue Vallo, Roselyne Rapoud, Delphine Quillet, Catherine Nguyen, Thuy Linh Nguyen, Quang Duc NhamThi, Tuyet Thanh Hoang Thi, Giang Feelemyer, Jonathan Hai, Vinh Vu Moles, Jean-Pierre Doan, Hong Quang Laureillard, Didier Des Jarlais, Don C. Nagot, Nicolas Michel, Laurent |
| description | •Regular heroin injection could be protective for depression and psychotic symptoms.•Psychiatric burden of methamphetamine use is high.•PWID treated with methadone are less often depressed.•Regular polysubstance use is associated with higher rate of psychiatric disorders.
Psychiatric comorbidities are frequent among people who inject drugs, they are associated with a poorer prognosis and need to be addressed. Their interaction with daily heroin injection requires clarification.
A cross-sectional survey was conducted among PWID recruited in the city of Haiphong, Vietnam, by respondent-driven sampling. The inclusion criteria were age 18 or older and current injection drug use, verified by skin marks and positive urine tests for heroin or methamphetamine. Data on socio-demographic characteristics, drug use, sexual behaviour and access to treatment were collected using face-to-face questionnaires by trained interviewers. PWID were screened by trained psychiatrists for depression, psychotic disorder and suicidality, using the MINI questionnaire.
418 participants were included in the analyses. All were injected heroin users, 21 % were diagnosed with a current major depressive disorder, 15 % with a current psychotic disorder and 12 % presented a suicide risk. In the bivariate analyses, regular meth use, cannabis use and ketamine use were positively associated with presenting at least one psychiatric condition while daily heroin injection and being currently treated with methadone were negatively associated. In the multivariate model, poly-substance use was positively associated with depression (methamphetamine and drinking in addition to heroin) and psychotic disorder (methamphetamine and/or hazardous drinking in addition to heroin) while daily heroin injection and current methadone treatment were negatively and independently associated with depression and psychotic syndrome.
Our survey confirms the burden of methamphetamine use and the protective effect of methadone but also a possible protective effect of daily heroin injection. |
| doi_str_mv | 10.1016/j.drugalcdep.2020.108334 |
| format | Article |
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Psychiatric comorbidities are frequent among people who inject drugs, they are associated with a poorer prognosis and need to be addressed. Their interaction with daily heroin injection requires clarification.
A cross-sectional survey was conducted among PWID recruited in the city of Haiphong, Vietnam, by respondent-driven sampling. The inclusion criteria were age 18 or older and current injection drug use, verified by skin marks and positive urine tests for heroin or methamphetamine. Data on socio-demographic characteristics, drug use, sexual behaviour and access to treatment were collected using face-to-face questionnaires by trained interviewers. PWID were screened by trained psychiatrists for depression, psychotic disorder and suicidality, using the MINI questionnaire.
418 participants were included in the analyses. All were injected heroin users, 21 % were diagnosed with a current major depressive disorder, 15 % with a current psychotic disorder and 12 % presented a suicide risk. In the bivariate analyses, regular meth use, cannabis use and ketamine use were positively associated with presenting at least one psychiatric condition while daily heroin injection and being currently treated with methadone were negatively associated. In the multivariate model, poly-substance use was positively associated with depression (methamphetamine and drinking in addition to heroin) and psychotic disorder (methamphetamine and/or hazardous drinking in addition to heroin) while daily heroin injection and current methadone treatment were negatively and independently associated with depression and psychotic syndrome.
Our survey confirms the burden of methamphetamine use and the protective effect of methadone but also a possible protective effect of daily heroin injection.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2020.108334</identifier><identifier>PMID: 33038638</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Bivariate analysis ; Cannabis ; Cross-Sectional Studies ; Demography ; Depression ; Depressive personality disorders ; Drinking ; Drinking behavior ; Drug abuse ; Drug use ; Dual disorder ; Female ; Heroin ; Heroin Dependence - diagnosis ; Heroin Dependence - epidemiology ; Heroin Dependence - psychology ; Humans ; Injection ; Ketamine ; Life Sciences ; Male ; Marijuana ; Medical prognosis ; Mental depression ; Mental disorders ; Mental Disorders - diagnosis ; Mental Disorders - epidemiology ; Mental Disorders - psychology ; Methadone ; Methamphetamine ; Middle Aged ; Polls & surveys ; Psychiatrists ; Psychosis ; Questionnaires ; Sexual behavior ; Sociodemographics ; Substance abuse ; Substance Abuse, Intravenous - diagnosis ; Substance Abuse, Intravenous - epidemiology ; Substance Abuse, Intravenous - psychology ; Substance use ; Suicide ; Surveys and Questionnaires ; Urine tests ; Vietnam - epidemiology</subject><ispartof>Drug and alcohol dependence, 2020-11, Vol.216, p.108334-108334, Article 108334</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Nov 1, 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c597t-9aa304186b81ae7ff3557cdfec2a9865734df77baf704a2861c52ad44e37820b3</citedby><cites>FETCH-LOGICAL-c597t-9aa304186b81ae7ff3557cdfec2a9865734df77baf704a2861c52ad44e37820b3</cites><orcidid>0000-0002-0104-9047 ; 0000-0002-2447-6754 ; 0000-0001-6617-4992 ; 0000-0002-0157-8168 ; 0000-0002-4068-8351 ; 0000-0002-2000-7838 ; 0000-0001-6130-7864 ; 0000-0002-6863-6350 ; 0000-0002-3493-2821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drugalcdep.2020.108334$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33038638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-02969004$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Le, Sao Mai</creatorcontrib><creatorcontrib>Trouiller, Philippe</creatorcontrib><creatorcontrib>Duong Thi, Huong</creatorcontrib><creatorcontrib>Khuat Thi Hai, Oanh</creatorcontrib><creatorcontrib>Pham Minh, Khue</creatorcontrib><creatorcontrib>Vallo, Roselyne</creatorcontrib><creatorcontrib>Rapoud, Delphine</creatorcontrib><creatorcontrib>Quillet, Catherine</creatorcontrib><creatorcontrib>Nguyen, Thuy Linh</creatorcontrib><creatorcontrib>Nguyen, Quang Duc</creatorcontrib><creatorcontrib>NhamThi, Tuyet Thanh</creatorcontrib><creatorcontrib>Hoang Thi, Giang</creatorcontrib><creatorcontrib>Feelemyer, Jonathan</creatorcontrib><creatorcontrib>Hai, Vinh Vu</creatorcontrib><creatorcontrib>Moles, Jean-Pierre</creatorcontrib><creatorcontrib>Doan, Hong Quang</creatorcontrib><creatorcontrib>Laureillard, Didier</creatorcontrib><creatorcontrib>Des Jarlais, Don C.</creatorcontrib><creatorcontrib>Nagot, Nicolas</creatorcontrib><creatorcontrib>Michel, Laurent</creatorcontrib><creatorcontrib>for the DRIVE Study Team</creatorcontrib><creatorcontrib>DRIVE Study Team</creatorcontrib><title>Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>•Regular heroin injection could be protective for depression and psychotic symptoms.•Psychiatric burden of methamphetamine use is high.•PWID treated with methadone are less often depressed.•Regular polysubstance use is associated with higher rate of psychiatric disorders.
Psychiatric comorbidities are frequent among people who inject drugs, they are associated with a poorer prognosis and need to be addressed. Their interaction with daily heroin injection requires clarification.
A cross-sectional survey was conducted among PWID recruited in the city of Haiphong, Vietnam, by respondent-driven sampling. The inclusion criteria were age 18 or older and current injection drug use, verified by skin marks and positive urine tests for heroin or methamphetamine. Data on socio-demographic characteristics, drug use, sexual behaviour and access to treatment were collected using face-to-face questionnaires by trained interviewers. PWID were screened by trained psychiatrists for depression, psychotic disorder and suicidality, using the MINI questionnaire.
418 participants were included in the analyses. All were injected heroin users, 21 % were diagnosed with a current major depressive disorder, 15 % with a current psychotic disorder and 12 % presented a suicide risk. In the bivariate analyses, regular meth use, cannabis use and ketamine use were positively associated with presenting at least one psychiatric condition while daily heroin injection and being currently treated with methadone were negatively associated. In the multivariate model, poly-substance use was positively associated with depression (methamphetamine and drinking in addition to heroin) and psychotic disorder (methamphetamine and/or hazardous drinking in addition to heroin) while daily heroin injection and current methadone treatment were negatively and independently associated with depression and psychotic syndrome.
Our survey confirms the burden of methamphetamine use and the protective effect of methadone but also a possible protective effect of daily heroin injection.</description><subject>Adult</subject><subject>Bivariate analysis</subject><subject>Cannabis</subject><subject>Cross-Sectional Studies</subject><subject>Demography</subject><subject>Depression</subject><subject>Depressive personality disorders</subject><subject>Drinking</subject><subject>Drinking behavior</subject><subject>Drug abuse</subject><subject>Drug use</subject><subject>Dual disorder</subject><subject>Female</subject><subject>Heroin</subject><subject>Heroin Dependence - diagnosis</subject><subject>Heroin Dependence - epidemiology</subject><subject>Heroin Dependence - psychology</subject><subject>Humans</subject><subject>Injection</subject><subject>Ketamine</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Marijuana</subject><subject>Medical prognosis</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Disorders - 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Psychiatric comorbidities are frequent among people who inject drugs, they are associated with a poorer prognosis and need to be addressed. Their interaction with daily heroin injection requires clarification.
A cross-sectional survey was conducted among PWID recruited in the city of Haiphong, Vietnam, by respondent-driven sampling. The inclusion criteria were age 18 or older and current injection drug use, verified by skin marks and positive urine tests for heroin or methamphetamine. Data on socio-demographic characteristics, drug use, sexual behaviour and access to treatment were collected using face-to-face questionnaires by trained interviewers. PWID were screened by trained psychiatrists for depression, psychotic disorder and suicidality, using the MINI questionnaire.
418 participants were included in the analyses. All were injected heroin users, 21 % were diagnosed with a current major depressive disorder, 15 % with a current psychotic disorder and 12 % presented a suicide risk. In the bivariate analyses, regular meth use, cannabis use and ketamine use were positively associated with presenting at least one psychiatric condition while daily heroin injection and being currently treated with methadone were negatively associated. In the multivariate model, poly-substance use was positively associated with depression (methamphetamine and drinking in addition to heroin) and psychotic disorder (methamphetamine and/or hazardous drinking in addition to heroin) while daily heroin injection and current methadone treatment were negatively and independently associated with depression and psychotic syndrome.
Our survey confirms the burden of methamphetamine use and the protective effect of methadone but also a possible protective effect of daily heroin injection.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33038638</pmid><doi>10.1016/j.drugalcdep.2020.108334</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0104-9047</orcidid><orcidid>https://orcid.org/0000-0002-2447-6754</orcidid><orcidid>https://orcid.org/0000-0001-6617-4992</orcidid><orcidid>https://orcid.org/0000-0002-0157-8168</orcidid><orcidid>https://orcid.org/0000-0002-4068-8351</orcidid><orcidid>https://orcid.org/0000-0002-2000-7838</orcidid><orcidid>https://orcid.org/0000-0001-6130-7864</orcidid><orcidid>https://orcid.org/0000-0002-6863-6350</orcidid><orcidid>https://orcid.org/0000-0002-3493-2821</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2020-11, Vol.216, p.108334-108334, Article 108334 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10290903 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Bivariate analysis Cannabis Cross-Sectional Studies Demography Depression Depressive personality disorders Drinking Drinking behavior Drug abuse Drug use Dual disorder Female Heroin Heroin Dependence - diagnosis Heroin Dependence - epidemiology Heroin Dependence - psychology Humans Injection Ketamine Life Sciences Male Marijuana Medical prognosis Mental depression Mental disorders Mental Disorders - diagnosis Mental Disorders - epidemiology Mental Disorders - psychology Methadone Methamphetamine Middle Aged Polls & surveys Psychiatrists Psychosis Questionnaires Sexual behavior Sociodemographics Substance abuse Substance Abuse, Intravenous - diagnosis Substance Abuse, Intravenous - epidemiology Substance Abuse, Intravenous - psychology Substance use Suicide Surveys and Questionnaires Urine tests Vietnam - epidemiology |
| title | Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T12%3A15%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Daily%20heroin%20injection%20and%20psychiatric%20disorders:%20A%20cross-sectional%20survey%20among%20People%20Who%20Inject%20Drugs%20(PWID)%20in%20Haiphong,%20Vietnam&rft.jtitle=Drug%20and%20alcohol%20dependence&rft.au=Le,%20Sao%20Mai&rft.aucorp=for%20the%20DRIVE%20Study%20Team&rft.date=2020-11-01&rft.volume=216&rft.spage=108334&rft.epage=108334&rft.pages=108334-108334&rft.artnum=108334&rft.issn=0376-8716&rft.eissn=1879-0046&rft_id=info:doi/10.1016/j.drugalcdep.2020.108334&rft_dat=%3Cproquest_pubme%3E2469840292%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2469840292&rft_id=info:pmid/33038638&rft_els_id=S0376871620304993&rfr_iscdi=true |