Determination of synthetic hallucinogens in oral fluids by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry
A fast and simple procedure based on microextraction by packed sorbent (MEPS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the simultaneous quantification of 28 synthetic hallucinogens in oral fluids, including lysergic acid diethylamide and substances from NB...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2023-07, Vol.415 (17), p.3607-3617 |
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| creator | Lesne, Evan Muñoz-Bartual, Miguel Esteve-Turrillas, Francesc A. |
| description | A fast and simple procedure based on microextraction by packed sorbent (MEPS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the simultaneous quantification of 28 synthetic hallucinogens in oral fluids, including lysergic acid diethylamide and substances from NBOMe, NBOH, NBF, 2C, and substituted amphetamine categories. Extraction conditions such as type of sorbent, sample pH, number of charge/discharge cycles, and elution volume were studied. Hallucinogenic compounds were extracted from oral fluid samples using C18 MEPS, loading with 100 μL sample (adjusted to pH 7) in 3 cycles, washing with 100 μL deionized water, and eluting with 50 μL methanol in 1 cycle, giving quantitative recoveries and no significant matrix effects. Limits of detection from 0.09 to 1.22 μg L
−1
; recoveries from 80 to 129% performed in spiked oral fluid samples at 20, 50, and 100 μg L
−1
; and high precision with relative standard deviations lower than 9% were obtained. The proposed methodology was demonstrated to be appropriate for the simple and sensitive determination of NBOMe derivates and other synthetic hallucinogenic substances in oral fluid samples.
Graphical Abstract |
| doi_str_mv | 10.1007/s00216-023-04751-2 |
| format | Article |
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−1
; recoveries from 80 to 129% performed in spiked oral fluid samples at 20, 50, and 100 μg L
−1
; and high precision with relative standard deviations lower than 9% were obtained. The proposed methodology was demonstrated to be appropriate for the simple and sensitive determination of NBOMe derivates and other synthetic hallucinogenic substances in oral fluid samples.
Graphical Abstract</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-023-04751-2</identifier><identifier>PMID: 37219582</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amphetamines ; Analytical Chemistry ; Biochemistry ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Chromatography, Liquid ; Deionization ; Extraction (Chemistry) ; Food Science ; Hallucinogenic drugs ; Hallucinogens ; Ions ; Laboratory Medicine ; Limit of Detection ; Liquid chromatography ; LSD ; Lysergic acid diethylamide ; Lysergide ; Mass spectrometry ; Mass spectroscopy ; Measurement ; Methods ; Monitoring/Environmental Analysis ; Oral fluids ; Research Paper ; Scientific imaging ; Solid Phase Microextraction - methods ; Sorbents ; Tandem Mass Spectrometry - methods</subject><ispartof>Analytical and bioanalytical chemistry, 2023-07, Vol.415 (17), p.3607-3617</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-79339e920ed9a6a5917fc3f4518ab69000b820d3111c5ce4727b87b41565091b3</citedby><cites>FETCH-LOGICAL-c542t-79339e920ed9a6a5917fc3f4518ab69000b820d3111c5ce4727b87b41565091b3</cites><orcidid>0000-0003-1543-1877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-023-04751-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-023-04751-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37219582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lesne, Evan</creatorcontrib><creatorcontrib>Muñoz-Bartual, Miguel</creatorcontrib><creatorcontrib>Esteve-Turrillas, Francesc A.</creatorcontrib><title>Determination of synthetic hallucinogens in oral fluids by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>A fast and simple procedure based on microextraction by packed sorbent (MEPS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the simultaneous quantification of 28 synthetic hallucinogens in oral fluids, including lysergic acid diethylamide and substances from NBOMe, NBOH, NBF, 2C, and substituted amphetamine categories. Extraction conditions such as type of sorbent, sample pH, number of charge/discharge cycles, and elution volume were studied. Hallucinogenic compounds were extracted from oral fluid samples using C18 MEPS, loading with 100 μL sample (adjusted to pH 7) in 3 cycles, washing with 100 μL deionized water, and eluting with 50 μL methanol in 1 cycle, giving quantitative recoveries and no significant matrix effects. Limits of detection from 0.09 to 1.22 μg L
−1
; recoveries from 80 to 129% performed in spiked oral fluid samples at 20, 50, and 100 μg L
−1
; and high precision with relative standard deviations lower than 9% were obtained. The proposed methodology was demonstrated to be appropriate for the simple and sensitive determination of NBOMe derivates and other synthetic hallucinogenic substances in oral fluid samples.
Graphical Abstract</description><subject>Amphetamines</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Liquid</subject><subject>Deionization</subject><subject>Extraction (Chemistry)</subject><subject>Food Science</subject><subject>Hallucinogenic drugs</subject><subject>Hallucinogens</subject><subject>Ions</subject><subject>Laboratory Medicine</subject><subject>Limit of Detection</subject><subject>Liquid chromatography</subject><subject>LSD</subject><subject>Lysergic acid diethylamide</subject><subject>Lysergide</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Measurement</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Oral fluids</subject><subject>Research Paper</subject><subject>Scientific imaging</subject><subject>Solid Phase Microextraction - 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methods</topic><topic>Chromatography, Liquid</topic><topic>Deionization</topic><topic>Extraction (Chemistry)</topic><topic>Food Science</topic><topic>Hallucinogenic drugs</topic><topic>Hallucinogens</topic><topic>Ions</topic><topic>Laboratory Medicine</topic><topic>Limit of Detection</topic><topic>Liquid chromatography</topic><topic>LSD</topic><topic>Lysergic acid diethylamide</topic><topic>Lysergide</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Measurement</topic><topic>Methods</topic><topic>Monitoring/Environmental Analysis</topic><topic>Oral fluids</topic><topic>Research Paper</topic><topic>Scientific imaging</topic><topic>Solid Phase Microextraction - methods</topic><topic>Sorbents</topic><topic>Tandem Mass Spectrometry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lesne, Evan</creatorcontrib><creatorcontrib>Muñoz-Bartual, Miguel</creatorcontrib><creatorcontrib>Esteve-Turrillas, Francesc A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lesne, Evan</au><au>Muñoz-Bartual, Miguel</au><au>Esteve-Turrillas, Francesc A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of synthetic hallucinogens in oral fluids by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>415</volume><issue>17</issue><spage>3607</spage><epage>3617</epage><pages>3607-3617</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>A fast and simple procedure based on microextraction by packed sorbent (MEPS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the simultaneous quantification of 28 synthetic hallucinogens in oral fluids, including lysergic acid diethylamide and substances from NBOMe, NBOH, NBF, 2C, and substituted amphetamine categories. Extraction conditions such as type of sorbent, sample pH, number of charge/discharge cycles, and elution volume were studied. Hallucinogenic compounds were extracted from oral fluid samples using C18 MEPS, loading with 100 μL sample (adjusted to pH 7) in 3 cycles, washing with 100 μL deionized water, and eluting with 50 μL methanol in 1 cycle, giving quantitative recoveries and no significant matrix effects. Limits of detection from 0.09 to 1.22 μg L
−1
; recoveries from 80 to 129% performed in spiked oral fluid samples at 20, 50, and 100 μg L
−1
; and high precision with relative standard deviations lower than 9% were obtained. The proposed methodology was demonstrated to be appropriate for the simple and sensitive determination of NBOMe derivates and other synthetic hallucinogenic substances in oral fluid samples.
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| ispartof | Analytical and bioanalytical chemistry, 2023-07, Vol.415 (17), p.3607-3617 |
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| subjects | Amphetamines Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography Chromatography, High Pressure Liquid - methods Chromatography, Liquid Deionization Extraction (Chemistry) Food Science Hallucinogenic drugs Hallucinogens Ions Laboratory Medicine Limit of Detection Liquid chromatography LSD Lysergic acid diethylamide Lysergide Mass spectrometry Mass spectroscopy Measurement Methods Monitoring/Environmental Analysis Oral fluids Research Paper Scientific imaging Solid Phase Microextraction - methods Sorbents Tandem Mass Spectrometry - methods |
| title | Determination of synthetic hallucinogens in oral fluids by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry |
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