Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion

•Kaempferol inhibits SARS-CoV-2 invasion by blocking viral membrane fusion.•Kaempferol is a pan-inhibitor of coronaviral fusion.•Kaempferol deforms HR1 of spike protein S2 subunit.•Kaempferol destabilizes highly conserved HR2 via lysine residues. The continuous evolution of SARS-CoV-2 has underscore...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-09, Vol.118, p.154942-154942, Article 154942
Hauptverfasser:	Gao, Junwei, Cao, Can, Shi, Mingfei, Hong, Shihao, Guo, Shijie, Li, Jing, Liang, Tengxiao, Song, Ping, Xu, Ruodan, Li, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral agents antivirals circular dichroism spectroscopy Coronavirus infections COVID-19 disease prevention endocytosis epithelium evolution fusion genetically modified organisms heptad repeats humans kaempferol luciferase lysine membrane fusion mutants Original polyacrylamide gel electrophoresis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus synthetic peptides virus replication
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