Kidney transplantation in an adult with transfusion-dependent beta thalassemia: A challenging case report and literature review
The markedly increased survival of transfusion-dependent beta thalassemia patients has led to the recognition of new complications, such as renal disorders. Kidney transplantation is nowadays the preferred treatment option for end-stage kidney disease (ESKD). We describe a case of a 49-year-old woma...
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Veröffentlicht in: | Archive of clinical cases 2023-01, Vol.10 (2), p.97-101 |
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description | The markedly increased survival of transfusion-dependent beta thalassemia patients has led to the recognition of new complications, such as renal disorders. Kidney transplantation is nowadays the preferred treatment option for end-stage kidney disease (ESKD). We describe a case of a 49-year-old woman with β-Transfusion Dependent Thalassemia, who developed ESKD as a result of focal segmental glomerulosclerosis and received a deceased-donor kidney transplant following hemodialysis for over a decade. The particular challenges of this case are discussed, including the long-term survival in hemodialysis. Our patient had to overcome multiple obstacles, including hypercoagulability issues presented in the form of thromboembolism, infections, such as hepatitis C and gastroenteritis, and the acute T-cell-mediated rejection, which had to be managed postoperatively. A review of the current literature revealed only one previous report of a thalassemia patient who successfully underwent renal transplantation. More than a year after the transplantation our patient presents with a normal glomerular filtration rate (GFR=62ml/min/1.73m
) and creatinine level (Cr=0.96mg/dL) and is transfused every 3 weeks. In conclusion, renal transplantation is possible in patients with TDT and should not be discouraged. Regular transfusions and optimal follow-up for the elimination of post-transplant complications are required. |
doi_str_mv | 10.22551/2023.39.1002.10250 |
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) and creatinine level (Cr=0.96mg/dL) and is transfused every 3 weeks. In conclusion, renal transplantation is possible in patients with TDT and should not be discouraged. Regular transfusions and optimal follow-up for the elimination of post-transplant complications are required.</description><identifier>ISSN: 2360-6975</identifier><identifier>EISSN: 2360-6975</identifier><identifier>DOI: 10.22551/2023.39.1002.10250</identifier><identifier>PMID: 37359087</identifier><language>eng</language><publisher>Romania: UMF “Gr. T. Popa” Iasi Publishing House</publisher><subject>Case Report</subject><ispartof>Archive of clinical cases, 2023-01, Vol.10 (2), p.97-101</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c208t-1812683d4cd129598c2db88d79b08a7bdd3d6acc29dc4c911110ecaae9dc8f1e3</cites><orcidid>0000-0002-0991-9983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289047/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289047/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37359087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalamara, Tsampika-Vasileia N</creatorcontrib><creatorcontrib>Zarkada, Evangelia G</creatorcontrib><creatorcontrib>Kasimatis, Efstratios D</creatorcontrib><creatorcontrib>Kofinas, Athanasios G</creatorcontrib><creatorcontrib>Klonizakis, Philippos I</creatorcontrib><creatorcontrib>Vlachaki, Efthymia C</creatorcontrib><creatorcontrib>Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</creatorcontrib><creatorcontrib>Adults Thalassemia Unit, Second Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</creatorcontrib><title>Kidney transplantation in an adult with transfusion-dependent beta thalassemia: A challenging case report and literature review</title><title>Archive of clinical cases</title><addtitle>Arch Clin Cases</addtitle><description>The markedly increased survival of transfusion-dependent beta thalassemia patients has led to the recognition of new complications, such as renal disorders. Kidney transplantation is nowadays the preferred treatment option for end-stage kidney disease (ESKD). We describe a case of a 49-year-old woman with β-Transfusion Dependent Thalassemia, who developed ESKD as a result of focal segmental glomerulosclerosis and received a deceased-donor kidney transplant following hemodialysis for over a decade. The particular challenges of this case are discussed, including the long-term survival in hemodialysis. Our patient had to overcome multiple obstacles, including hypercoagulability issues presented in the form of thromboembolism, infections, such as hepatitis C and gastroenteritis, and the acute T-cell-mediated rejection, which had to be managed postoperatively. A review of the current literature revealed only one previous report of a thalassemia patient who successfully underwent renal transplantation. More than a year after the transplantation our patient presents with a normal glomerular filtration rate (GFR=62ml/min/1.73m
) and creatinine level (Cr=0.96mg/dL) and is transfused every 3 weeks. In conclusion, renal transplantation is possible in patients with TDT and should not be discouraged. Regular transfusions and optimal follow-up for the elimination of post-transplant complications are required.</description><subject>Case Report</subject><issn>2360-6975</issn><issn>2360-6975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVkdtOAyEQhonRqNE-gYnhBbZy6HbBG2OMp2jijV6TWZi2mC27AarxyleXtmqUEIZh5v8hfISccDYWoq75mWBCjqUec8ZEWUTNdsihkFNWTXVT7_7ZH5BRSq-s9DEuZcP3yYFsZK2Zag7J54N3AT9ojhDS0EHIkH0fqA8UynSrLtN3nxfbhtkqlWLlcMDgMGTaYgaaF9BBSrj0cE4vqS1ph2Huw5xaSEgjDn3Mxc_RzmeMkFdxffrm8f2Y7M2gSzj6jkfk5eb6-equeny6vb-6fKysYCpXXHExVdJNrONC11pZ4VqlXKNbpqBpnZNuCtYK7ezEal4GQwuAJVczjvKIXGx9h1W7RGfL4yN0Zoh-CfHD9ODN_0rwCzPv30z5WqXZpCkOcutgY59SxNmvmDOzYWLWTIzUZs3EbJgU1enfe381PwTkF7h1i-s</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Kalamara, Tsampika-Vasileia N</creator><creator>Zarkada, Evangelia G</creator><creator>Kasimatis, Efstratios D</creator><creator>Kofinas, Athanasios G</creator><creator>Klonizakis, Philippos I</creator><creator>Vlachaki, Efthymia C</creator><general>UMF “Gr. 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Popa” Iasi Publishing House</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0991-9983</orcidid></search><sort><creationdate>20230101</creationdate><title>Kidney transplantation in an adult with transfusion-dependent beta thalassemia: A challenging case report and literature review</title><author>Kalamara, Tsampika-Vasileia N ; Zarkada, Evangelia G ; Kasimatis, Efstratios D ; Kofinas, Athanasios G ; Klonizakis, Philippos I ; Vlachaki, Efthymia C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c208t-1812683d4cd129598c2db88d79b08a7bdd3d6acc29dc4c911110ecaae9dc8f1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Case Report</topic><toplevel>online_resources</toplevel><creatorcontrib>Kalamara, Tsampika-Vasileia N</creatorcontrib><creatorcontrib>Zarkada, Evangelia G</creatorcontrib><creatorcontrib>Kasimatis, Efstratios D</creatorcontrib><creatorcontrib>Kofinas, Athanasios G</creatorcontrib><creatorcontrib>Klonizakis, Philippos I</creatorcontrib><creatorcontrib>Vlachaki, Efthymia C</creatorcontrib><creatorcontrib>Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</creatorcontrib><creatorcontrib>Adults Thalassemia Unit, Second Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archive of clinical cases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalamara, Tsampika-Vasileia N</au><au>Zarkada, Evangelia G</au><au>Kasimatis, Efstratios D</au><au>Kofinas, Athanasios G</au><au>Klonizakis, Philippos I</au><au>Vlachaki, Efthymia C</au><aucorp>Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</aucorp><aucorp>Adults Thalassemia Unit, Second Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney transplantation in an adult with transfusion-dependent beta thalassemia: A challenging case report and literature review</atitle><jtitle>Archive of clinical cases</jtitle><addtitle>Arch Clin Cases</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>10</volume><issue>2</issue><spage>97</spage><epage>101</epage><pages>97-101</pages><issn>2360-6975</issn><eissn>2360-6975</eissn><abstract>The markedly increased survival of transfusion-dependent beta thalassemia patients has led to the recognition of new complications, such as renal disorders. Kidney transplantation is nowadays the preferred treatment option for end-stage kidney disease (ESKD). We describe a case of a 49-year-old woman with β-Transfusion Dependent Thalassemia, who developed ESKD as a result of focal segmental glomerulosclerosis and received a deceased-donor kidney transplant following hemodialysis for over a decade. The particular challenges of this case are discussed, including the long-term survival in hemodialysis. Our patient had to overcome multiple obstacles, including hypercoagulability issues presented in the form of thromboembolism, infections, such as hepatitis C and gastroenteritis, and the acute T-cell-mediated rejection, which had to be managed postoperatively. A review of the current literature revealed only one previous report of a thalassemia patient who successfully underwent renal transplantation. More than a year after the transplantation our patient presents with a normal glomerular filtration rate (GFR=62ml/min/1.73m
) and creatinine level (Cr=0.96mg/dL) and is transfused every 3 weeks. In conclusion, renal transplantation is possible in patients with TDT and should not be discouraged. Regular transfusions and optimal follow-up for the elimination of post-transplant complications are required.</abstract><cop>Romania</cop><pub>UMF “Gr. T. Popa” Iasi Publishing House</pub><pmid>37359087</pmid><doi>10.22551/2023.39.1002.10250</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0991-9983</orcidid><oa>free_for_read</oa></addata></record> |
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title | Kidney transplantation in an adult with transfusion-dependent beta thalassemia: A challenging case report and literature review |
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