Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy
In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu ions as a photosensitizer for photod...
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| Veröffentlicht in: | RSC advances 2023-06, Vol.13 (28), p.19079-19090 |
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| container_title | RSC advances |
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| creator | Huang, Yu-Ya Lee, Zui-Harng Chang, Kai-Chi Wu, Zhi-Yuan Lee, Cheng-Chang Tsou, Min-Hsuan Lin, Hsiu-Mei |
| description | In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu
ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd
ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment. |
| doi_str_mv | 10.1039/d3ra02068a |
| format | Article |
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ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd
ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d3ra02068a</identifier><identifier>PMID: 37362343</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Bismuth ; Cancer ; Cancer therapies ; Chemistry ; Drug delivery systems ; Folic acid ; Gadolinium ; Hyaluronic acid ; Irradiation ; Magnetic resonance imaging ; Nanoparticles ; Silicon dioxide ; Survival ; Toxicity</subject><ispartof>RSC advances, 2023-06, Vol.13 (28), p.19079-19090</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2023</rights><rights>This journal is © The Royal Society of Chemistry 2023 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-5a4b8a5f4e1cedb4a47c9962b555a8db6464b73ec624f0ec3b1c2fd374c9bb353</citedby><cites>FETCH-LOGICAL-c407t-5a4b8a5f4e1cedb4a47c9962b555a8db6464b73ec624f0ec3b1c2fd374c9bb353</cites><orcidid>0000-0002-5185-7448 ; 0000-0002-1973-2346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288219/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288219/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37362343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Yu-Ya</creatorcontrib><creatorcontrib>Lee, Zui-Harng</creatorcontrib><creatorcontrib>Chang, Kai-Chi</creatorcontrib><creatorcontrib>Wu, Zhi-Yuan</creatorcontrib><creatorcontrib>Lee, Cheng-Chang</creatorcontrib><creatorcontrib>Tsou, Min-Hsuan</creatorcontrib><creatorcontrib>Lin, Hsiu-Mei</creatorcontrib><title>Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu
ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd
ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment.</description><subject>Bismuth</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemistry</subject><subject>Drug delivery systems</subject><subject>Folic acid</subject><subject>Gadolinium</subject><subject>Hyaluronic acid</subject><subject>Irradiation</subject><subject>Magnetic resonance imaging</subject><subject>Nanoparticles</subject><subject>Silicon dioxide</subject><subject>Survival</subject><subject>Toxicity</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkV9LHTEQxYNYqlhf-gEk0BcpbJv_u_skF6ttwVIQ-xwm2ey9kb3JNsla_PbNVSvaeZkZ8uNwMgeh95R8ooT3nweegDCiOthDh4wI1dSl338xH6DjnG9JLSUpU_QtOuAtV4wLfoiWHy7HOaa4ZJz95C3gACHOkIq3k8v4jy8bPCwwNQXS2hUf1hjWydtlKkuCCee4JFvBMSbswgaCdQO2u5ZwSQ7K1oWC7zzUrWq5BPP9O_RmhCm746d-hH5dXtycf2uufn79fr66aqwgbWkkCNOBHIWjVdQIEK3te8WMlBK6wSihhGm5s4qJkTjLDbVsHHgrbG8Ml_wInT3qzovZusFWJ9WynpPfQrrXEbx-_RL8Rq_jnaaEdR2jfVU4fVJI8ffictFbn62bJgiu3kyzjhNGec936If_0Nt6mlD_90BJ1inZVerjI2VTzDm58dkNJXqXqP7Cr1cPia4qfPLS_zP6Lz_-F1Kqn3w</recordid><startdate>20230622</startdate><enddate>20230622</enddate><creator>Huang, Yu-Ya</creator><creator>Lee, Zui-Harng</creator><creator>Chang, Kai-Chi</creator><creator>Wu, Zhi-Yuan</creator><creator>Lee, Cheng-Chang</creator><creator>Tsou, Min-Hsuan</creator><creator>Lin, Hsiu-Mei</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5185-7448</orcidid><orcidid>https://orcid.org/0000-0002-1973-2346</orcidid></search><sort><creationdate>20230622</creationdate><title>Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy</title><author>Huang, Yu-Ya ; Lee, Zui-Harng ; Chang, Kai-Chi ; Wu, Zhi-Yuan ; Lee, Cheng-Chang ; Tsou, Min-Hsuan ; Lin, Hsiu-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-5a4b8a5f4e1cedb4a47c9962b555a8db6464b73ec624f0ec3b1c2fd374c9bb353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bismuth</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemistry</topic><topic>Drug delivery systems</topic><topic>Folic acid</topic><topic>Gadolinium</topic><topic>Hyaluronic acid</topic><topic>Irradiation</topic><topic>Magnetic resonance imaging</topic><topic>Nanoparticles</topic><topic>Silicon dioxide</topic><topic>Survival</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yu-Ya</creatorcontrib><creatorcontrib>Lee, Zui-Harng</creatorcontrib><creatorcontrib>Chang, Kai-Chi</creatorcontrib><creatorcontrib>Wu, Zhi-Yuan</creatorcontrib><creatorcontrib>Lee, Cheng-Chang</creatorcontrib><creatorcontrib>Tsou, Min-Hsuan</creatorcontrib><creatorcontrib>Lin, Hsiu-Mei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Yu-Ya</au><au>Lee, Zui-Harng</au><au>Chang, Kai-Chi</au><au>Wu, Zhi-Yuan</au><au>Lee, Cheng-Chang</au><au>Tsou, Min-Hsuan</au><au>Lin, Hsiu-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2023-06-22</date><risdate>2023</risdate><volume>13</volume><issue>28</issue><spage>19079</spage><epage>19090</epage><pages>19079-19090</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu
ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd
ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL
of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37362343</pmid><doi>10.1039/d3ra02068a</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-5185-7448</orcidid><orcidid>https://orcid.org/0000-0002-1973-2346</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Bismuth Cancer Cancer therapies Chemistry Drug delivery systems Folic acid Gadolinium Hyaluronic acid Irradiation Magnetic resonance imaging Nanoparticles Silicon dioxide Survival Toxicity |
| title | Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy |
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