CAR-T Cells and the Kidney: Insights from the WHO Safety Database

Background Chimeric antigen receptor T (CAR-T) cells have proven to be a game changer for treating several hematologic malignancies. Randomized controlled trials have highlighted potential life-threatening adverse drug reactions (ADRs), including cytokine release syndrome (CRS). Acute renal failure...

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Veröffentlicht in:	BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy biopharmaceuticals, and gene therapy, 2023-07, Vol.37 (4), p.521-530
Hauptverfasser:	Gérard, Alexandre O., Merino, Diane, Charbinat, Alexis, Fournier, Joseph, Destere, Alexandre, Loschi, Michael, Cluzeau, Thomas, Sicard, Antoine, Drici, Milou-Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Antibodies Antigens Biomedical and Life Sciences Biomedicine Cancer Research Cell therapy Chimeric antigen receptors Clinical trials Confidence intervals Cytokines Drug-Related Side Effects and Adverse Reactions Humans Hypercalcemia Hypernatremia Hyperphosphatemia Hyponatremia Hypophosphatemia Kidney Kidneys Lymphocytes Lymphocytes T Lymphoma Malignancy Medical personnel Metabolic acidosis Metabolism Molecular Medicine Original Original Research Article Pharmaceutical industry Pharmacotherapy Pharmacovigilance Receptors, Chimeric Antigen Renal failure Renal Insufficiency Variables World Health Organization
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