Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity
•We compared quiescent epochs in human EEG acquired during anesthetic BS and PGES following ECT-induced generalized seizures.•Quiescent periods during PGES showed greater amplitude than during BS with stronger relative delta power across the scalp.•Quantitative analyses reveal distinct profiles for...
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| Veröffentlicht in: | Clinical neurophysiology 2022-10, Vol.142, p.125-132 |
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| creator | Kafashan, MohammadMehdi Brian Hickman, L. Labonte, Alyssa K. Huels, Emma R. Maybrier, Hannah Guay, Christian S. Subramanian, Subha Farber, Nuri B. Ching, ShiNung Hogan, R. Edward Kelz, Max B. Avidan, Michael S. Mashour, George A. Palanca, Ben J.A. |
| description | •We compared quiescent epochs in human EEG acquired during anesthetic BS and PGES following ECT-induced generalized seizures.•Quiescent periods during PGES showed greater amplitude than during BS with stronger relative delta power across the scalp.•Quantitative analyses reveal distinct profiles for PGES and BS quiescent periods across voltage, frequency, and spatial domains.
Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.
We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.
The median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p |
| doi_str_mv | 10.1016/j.clinph.2022.07.493 |
| format | Article |
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Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.
We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.
The median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p < 0.001). Relative power was greater for quiescence during PGES than BS for the 1–4 Hz delta band (p < 0.001), at the expense of power in the theta (4–8 Hz, p < 0.001), beta (13–30 Hz, p = 0.04) and gamma (30–70 Hz, p = 0.006) frequency bands. Topographic analyses revealed that amplitude across the scalp was consistently higher for quiescent periods during PGES than BS, whose voltage was within the noise floor.
Quiescent epochs during PGES and BS have distinct patterns of EEG signals across voltage, frequency, and spatial domains.
Quiescent epochs during PGES and BS, important neurophysiological markers for clinical outcomes, are shown to have distinct voltage and frequency characteristics.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2022.07.493</identifier><identifier>PMID: 36030576</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Algorithms ; Anesthesia ; Burst suppression ; Electroconvulsive Therapy ; Electroencephalography ; Humans ; Isoflurane ; Major depressive disorder ; Postictal generalized electroencephalographic suppression ; Seizures ; Seizures - diagnosis</subject><ispartof>Clinical neurophysiology, 2022-10, Vol.142, p.125-132</ispartof><rights>2022 International Federation of Clinical Neurophysiology</rights><rights>Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-5fc5d1f1f1981a17e8bd20f51f1cfd69b7d3adde79ba3d5d8eb0b78d47904ce13</citedby><cites>FETCH-LOGICAL-c464t-5fc5d1f1f1981a17e8bd20f51f1cfd69b7d3adde79ba3d5d8eb0b78d47904ce13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1388245722008215$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36030576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kafashan, MohammadMehdi</creatorcontrib><creatorcontrib>Brian Hickman, L.</creatorcontrib><creatorcontrib>Labonte, Alyssa K.</creatorcontrib><creatorcontrib>Huels, Emma R.</creatorcontrib><creatorcontrib>Maybrier, Hannah</creatorcontrib><creatorcontrib>Guay, Christian S.</creatorcontrib><creatorcontrib>Subramanian, Subha</creatorcontrib><creatorcontrib>Farber, Nuri B.</creatorcontrib><creatorcontrib>Ching, ShiNung</creatorcontrib><creatorcontrib>Hogan, R. Edward</creatorcontrib><creatorcontrib>Kelz, Max B.</creatorcontrib><creatorcontrib>Avidan, Michael S.</creatorcontrib><creatorcontrib>Mashour, George A.</creatorcontrib><creatorcontrib>Palanca, Ben J.A.</creatorcontrib><title>Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>•We compared quiescent epochs in human EEG acquired during anesthetic BS and PGES following ECT-induced generalized seizures.•Quiescent periods during PGES showed greater amplitude than during BS with stronger relative delta power across the scalp.•Quantitative analyses reveal distinct profiles for PGES and BS quiescent periods across voltage, frequency, and spatial domains.
Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.
We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.
The median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p < 0.001). Relative power was greater for quiescence during PGES than BS for the 1–4 Hz delta band (p < 0.001), at the expense of power in the theta (4–8 Hz, p < 0.001), beta (13–30 Hz, p = 0.04) and gamma (30–70 Hz, p = 0.006) frequency bands. Topographic analyses revealed that amplitude across the scalp was consistently higher for quiescent periods during PGES than BS, whose voltage was within the noise floor.
Quiescent epochs during PGES and BS have distinct patterns of EEG signals across voltage, frequency, and spatial domains.
Quiescent epochs during PGES and BS, important neurophysiological markers for clinical outcomes, are shown to have distinct voltage and frequency characteristics.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Anesthesia</subject><subject>Burst suppression</subject><subject>Electroconvulsive Therapy</subject><subject>Electroencephalography</subject><subject>Humans</subject><subject>Isoflurane</subject><subject>Major depressive disorder</subject><subject>Postictal generalized electroencephalographic suppression</subject><subject>Seizures</subject><subject>Seizures - diagnosis</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu3CAQhlGVqkmTvEFUcczFDmBs8CVVFW3TSJGqSu0ZYRhvWHnBBbxS-vRlu0mUXCoOg5h__hnmQ-iCkpoS2l1tajM5Pz_UjDBWE1HzvnmHTqgUrJJ9y47KvZGyYrwVx-hjShtCiCCcfUDHTUca0oruBIUfi4NkwBvAdonOr_GwxJRxWuY5QkoueKy9xXNI2ZmsJ7wGD1FP7g9YvFrdvlXGYuOK0puMZ50zRJ9wGLE22e1cfjxD70c9JTh_iqfo19fVz5tv1f3327ubL_eV4R3PVTua1tKxnF5STQXIwTIytuXBjLbrB2EbbS2IftCNba2EgQxCWi56wg3Q5hR9PvjOy7AFWz6Yy8xqjm6r46MK2qm3Ge8e1DrsFCVMipbvHS6fHGL4vUDKauvKoqZJewhLUkwQIUXH_kn5QWpiSCnC-NKHErWHpTbqAEvtYSkiVIFVyj69nvGl6JlOEVwfBFA2tXMQVTJuj8q6CCYrG9z_O_wFdbGsvg</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Kafashan, MohammadMehdi</creator><creator>Brian Hickman, L.</creator><creator>Labonte, Alyssa K.</creator><creator>Huels, Emma R.</creator><creator>Maybrier, Hannah</creator><creator>Guay, Christian S.</creator><creator>Subramanian, Subha</creator><creator>Farber, Nuri B.</creator><creator>Ching, ShiNung</creator><creator>Hogan, R. 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Edward</creatorcontrib><creatorcontrib>Kelz, Max B.</creatorcontrib><creatorcontrib>Avidan, Michael S.</creatorcontrib><creatorcontrib>Mashour, George A.</creatorcontrib><creatorcontrib>Palanca, Ben J.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kafashan, MohammadMehdi</au><au>Brian Hickman, L.</au><au>Labonte, Alyssa K.</au><au>Huels, Emma R.</au><au>Maybrier, Hannah</au><au>Guay, Christian S.</au><au>Subramanian, Subha</au><au>Farber, Nuri B.</au><au>Ching, ShiNung</au><au>Hogan, R. Edward</au><au>Kelz, Max B.</au><au>Avidan, Michael S.</au><au>Mashour, George A.</au><au>Palanca, Ben J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>142</volume><spage>125</spage><epage>132</epage><pages>125-132</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>•We compared quiescent epochs in human EEG acquired during anesthetic BS and PGES following ECT-induced generalized seizures.•Quiescent periods during PGES showed greater amplitude than during BS with stronger relative delta power across the scalp.•Quantitative analyses reveal distinct profiles for PGES and BS quiescent periods across voltage, frequency, and spatial domains.
Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.
We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.
The median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p < 0.001). Relative power was greater for quiescence during PGES than BS for the 1–4 Hz delta band (p < 0.001), at the expense of power in the theta (4–8 Hz, p < 0.001), beta (13–30 Hz, p = 0.04) and gamma (30–70 Hz, p = 0.006) frequency bands. Topographic analyses revealed that amplitude across the scalp was consistently higher for quiescent periods during PGES than BS, whose voltage was within the noise floor.
Quiescent epochs during PGES and BS have distinct patterns of EEG signals across voltage, frequency, and spatial domains.
Quiescent epochs during PGES and BS, important neurophysiological markers for clinical outcomes, are shown to have distinct voltage and frequency characteristics.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36030576</pmid><doi>10.1016/j.clinph.2022.07.493</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Algorithms Anesthesia Burst suppression Electroconvulsive Therapy Electroencephalography Humans Isoflurane Major depressive disorder Postictal generalized electroencephalographic suppression Seizures Seizures - diagnosis |
| title | Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity |
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