Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI
Introduction/aims Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–T...
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| Veröffentlicht in: | Muscle & nerve 2022-12, Vol.66 (6), p.744-749 |
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| creator | Elmansy, Mostafa Morrow, Jasper M. Shah, Sachit Fischmann, Arne Wastling, Stephen Reilly, Mary M. Hanna, Michael G. Helmy, Eman Mohamed El‐Essawy, Saleh Saleh Thornton, John S. Yousry, Tarek A. |
| description | Introduction/aims
Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).
Methods
MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross‐sectional area (CSA) was measured at the mid‐thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.
Results
A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age‐ and sex‐matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mm2 (IBM) vs. 35.5 ± 9.9 mm2 (controls), p |
| doi_str_mv | 10.1002/mus.27728 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10286743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2737275296</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4448-4904b2ac145c0ed4ba2f95202db64938322bbd254cdbedc73b9b753b07392e313</originalsourceid><addsrcrecordid>eNp1kVtLwzAYhoMoOqcX_gEJeKMX05zaNFciYx5AETzA7kKTZi7SNjVpN_rvjU6HCl4Fvjw8vN_3AnCA0SlGiJxVXTglnJNsAwwwEnzEEpFtggHCLBulVEx3wG4IrwghnKV8G-zQFCc48gMwnSxsYWptoJvB2viFgfO-Mb71rpn30NawyVtr6jbApW3ncaDLLlhXQ-WKHla9C7a1AcZB6ZbGw9JWCt493OyBrVleBrP_9Q7B8-XkaXw9ur2_uhlf3I40YzEdE4gpkmvMEo1MwVROZiIhiBQqZYJmlBClCpIwXShTaE6VUDyhCnEqiKGYDsH5ytt0qopEjOrzUjbeVrnvpcut_P1T27l8cQuJEYnHYDQajr8M3r11JrSyskGbssxr47ogCcc8zWJYEdGjP-ir63wd94sU5YQnRKSROllR2rsQvJmt02AkPwqT1ac2FhDZw5_x1-R3QxE4WwFLW5r-f5O8e35cKd8Bckqg1w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2737275296</pqid></control><display><type>article</type><title>Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Elmansy, Mostafa ; Morrow, Jasper M. ; Shah, Sachit ; Fischmann, Arne ; Wastling, Stephen ; Reilly, Mary M. ; Hanna, Michael G. ; Helmy, Eman Mohamed ; El‐Essawy, Saleh Saleh ; Thornton, John S. ; Yousry, Tarek A.</creator><creatorcontrib>Elmansy, Mostafa ; Morrow, Jasper M. ; Shah, Sachit ; Fischmann, Arne ; Wastling, Stephen ; Reilly, Mary M. ; Hanna, Michael G. ; Helmy, Eman Mohamed ; El‐Essawy, Saleh Saleh ; Thornton, John S. ; Yousry, Tarek A.</creatorcontrib><description>Introduction/aims
Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).
Methods
MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross‐sectional area (CSA) was measured at the mid‐thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.
Results
A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age‐ and sex‐matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mm2 (IBM) vs. 35.5 ± 9.9 mm2 (controls), p < 0.001; and 96.9 ± 35.5 mm2 (CMT1A) vs. 35.5 ± 9.9 mm2 (controls); p < 0.001). Tibial nerve CSA was also enlarged in IBM and CMT1 patients compared to controls.
Discussion
MRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.27728</identifier><identifier>PMID: 36151728</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Charcot-Marie-Tooth disease ; Charcot-Marie-Tooth Disease - complications ; Charcot-Marie-Tooth Disease - diagnostic imaging ; Clinical ; Clinical s ; Humans ; Hypertrophy ; Hypertrophy - diagnostic imaging ; inclusion body myositis ; Inflammatory diseases ; Lower Extremity - diagnostic imaging ; Magnetic resonance ; Magnetic Resonance Imaging ; magnetic resonance neurography ; Musculoskeletal diseases ; Myositis ; Myositis, Inclusion Body - complications ; Myositis, Inclusion Body - diagnostic imaging ; nerve enlargement ; Nerves ; Patients ; Polyneuropathy ; Sciatic nerve ; Thigh ; Tibial nerve</subject><ispartof>Muscle & nerve, 2022-12, Vol.66 (6), p.744-749</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4448-4904b2ac145c0ed4ba2f95202db64938322bbd254cdbedc73b9b753b07392e313</citedby><cites>FETCH-LOGICAL-c4448-4904b2ac145c0ed4ba2f95202db64938322bbd254cdbedc73b9b753b07392e313</cites><orcidid>0000-0001-9812-6418</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.27728$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.27728$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36151728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elmansy, Mostafa</creatorcontrib><creatorcontrib>Morrow, Jasper M.</creatorcontrib><creatorcontrib>Shah, Sachit</creatorcontrib><creatorcontrib>Fischmann, Arne</creatorcontrib><creatorcontrib>Wastling, Stephen</creatorcontrib><creatorcontrib>Reilly, Mary M.</creatorcontrib><creatorcontrib>Hanna, Michael G.</creatorcontrib><creatorcontrib>Helmy, Eman Mohamed</creatorcontrib><creatorcontrib>El‐Essawy, Saleh Saleh</creatorcontrib><creatorcontrib>Thornton, John S.</creatorcontrib><creatorcontrib>Yousry, Tarek A.</creatorcontrib><title>Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction/aims
Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).
Methods
MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross‐sectional area (CSA) was measured at the mid‐thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.
Results
A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age‐ and sex‐matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mm2 (IBM) vs. 35.5 ± 9.9 mm2 (controls), p < 0.001; and 96.9 ± 35.5 mm2 (CMT1A) vs. 35.5 ± 9.9 mm2 (controls); p < 0.001). Tibial nerve CSA was also enlarged in IBM and CMT1 patients compared to controls.
Discussion
MRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically.</description><subject>Charcot-Marie-Tooth disease</subject><subject>Charcot-Marie-Tooth Disease - complications</subject><subject>Charcot-Marie-Tooth Disease - diagnostic imaging</subject><subject>Clinical</subject><subject>Clinical s</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Hypertrophy - diagnostic imaging</subject><subject>inclusion body myositis</subject><subject>Inflammatory diseases</subject><subject>Lower Extremity - diagnostic imaging</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>magnetic resonance neurography</subject><subject>Musculoskeletal diseases</subject><subject>Myositis</subject><subject>Myositis, Inclusion Body - complications</subject><subject>Myositis, Inclusion Body - diagnostic imaging</subject><subject>nerve enlargement</subject><subject>Nerves</subject><subject>Patients</subject><subject>Polyneuropathy</subject><subject>Sciatic nerve</subject><subject>Thigh</subject><subject>Tibial nerve</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kVtLwzAYhoMoOqcX_gEJeKMX05zaNFciYx5AETzA7kKTZi7SNjVpN_rvjU6HCl4Fvjw8vN_3AnCA0SlGiJxVXTglnJNsAwwwEnzEEpFtggHCLBulVEx3wG4IrwghnKV8G-zQFCc48gMwnSxsYWptoJvB2viFgfO-Mb71rpn30NawyVtr6jbApW3ncaDLLlhXQ-WKHla9C7a1AcZB6ZbGw9JWCt493OyBrVleBrP_9Q7B8-XkaXw9ur2_uhlf3I40YzEdE4gpkmvMEo1MwVROZiIhiBQqZYJmlBClCpIwXShTaE6VUDyhCnEqiKGYDsH5ytt0qopEjOrzUjbeVrnvpcut_P1T27l8cQuJEYnHYDQajr8M3r11JrSyskGbssxr47ogCcc8zWJYEdGjP-ir63wd94sU5YQnRKSROllR2rsQvJmt02AkPwqT1ac2FhDZw5_x1-R3QxE4WwFLW5r-f5O8e35cKd8Bckqg1w</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Elmansy, Mostafa</creator><creator>Morrow, Jasper M.</creator><creator>Shah, Sachit</creator><creator>Fischmann, Arne</creator><creator>Wastling, Stephen</creator><creator>Reilly, Mary M.</creator><creator>Hanna, Michael G.</creator><creator>Helmy, Eman Mohamed</creator><creator>El‐Essawy, Saleh Saleh</creator><creator>Thornton, John S.</creator><creator>Yousry, Tarek A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9812-6418</orcidid></search><sort><creationdate>202212</creationdate><title>Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI</title><author>Elmansy, Mostafa ; Morrow, Jasper M. ; Shah, Sachit ; Fischmann, Arne ; Wastling, Stephen ; Reilly, Mary M. ; Hanna, Michael G. ; Helmy, Eman Mohamed ; El‐Essawy, Saleh Saleh ; Thornton, John S. ; Yousry, Tarek A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4448-4904b2ac145c0ed4ba2f95202db64938322bbd254cdbedc73b9b753b07392e313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Charcot-Marie-Tooth disease</topic><topic>Charcot-Marie-Tooth Disease - complications</topic><topic>Charcot-Marie-Tooth Disease - diagnostic imaging</topic><topic>Clinical</topic><topic>Clinical s</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Hypertrophy - diagnostic imaging</topic><topic>inclusion body myositis</topic><topic>Inflammatory diseases</topic><topic>Lower Extremity - diagnostic imaging</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>magnetic resonance neurography</topic><topic>Musculoskeletal diseases</topic><topic>Myositis</topic><topic>Myositis, Inclusion Body - complications</topic><topic>Myositis, Inclusion Body - diagnostic imaging</topic><topic>nerve enlargement</topic><topic>Nerves</topic><topic>Patients</topic><topic>Polyneuropathy</topic><topic>Sciatic nerve</topic><topic>Thigh</topic><topic>Tibial nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elmansy, Mostafa</creatorcontrib><creatorcontrib>Morrow, Jasper M.</creatorcontrib><creatorcontrib>Shah, Sachit</creatorcontrib><creatorcontrib>Fischmann, Arne</creatorcontrib><creatorcontrib>Wastling, Stephen</creatorcontrib><creatorcontrib>Reilly, Mary M.</creatorcontrib><creatorcontrib>Hanna, Michael G.</creatorcontrib><creatorcontrib>Helmy, Eman Mohamed</creatorcontrib><creatorcontrib>El‐Essawy, Saleh Saleh</creatorcontrib><creatorcontrib>Thornton, John S.</creatorcontrib><creatorcontrib>Yousry, Tarek A.</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elmansy, Mostafa</au><au>Morrow, Jasper M.</au><au>Shah, Sachit</au><au>Fischmann, Arne</au><au>Wastling, Stephen</au><au>Reilly, Mary M.</au><au>Hanna, Michael G.</au><au>Helmy, Eman Mohamed</au><au>El‐Essawy, Saleh Saleh</au><au>Thornton, John S.</au><au>Yousry, Tarek A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2022-12</date><risdate>2022</risdate><volume>66</volume><issue>6</issue><spage>744</spage><epage>749</epage><pages>744-749</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction/aims
Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).
Methods
MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross‐sectional area (CSA) was measured at the mid‐thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.
Results
A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age‐ and sex‐matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mm2 (IBM) vs. 35.5 ± 9.9 mm2 (controls), p < 0.001; and 96.9 ± 35.5 mm2 (CMT1A) vs. 35.5 ± 9.9 mm2 (controls); p < 0.001). Tibial nerve CSA was also enlarged in IBM and CMT1 patients compared to controls.
Discussion
MRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36151728</pmid><doi>10.1002/mus.27728</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9812-6418</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Charcot-Marie-Tooth disease Charcot-Marie-Tooth Disease - complications Charcot-Marie-Tooth Disease - diagnostic imaging Clinical Clinical s Humans Hypertrophy Hypertrophy - diagnostic imaging inclusion body myositis Inflammatory diseases Lower Extremity - diagnostic imaging Magnetic resonance Magnetic Resonance Imaging magnetic resonance neurography Musculoskeletal diseases Myositis Myositis, Inclusion Body - complications Myositis, Inclusion Body - diagnostic imaging nerve enlargement Nerves Patients Polyneuropathy Sciatic nerve Thigh Tibial nerve |
| title | Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI |
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