Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration
Background/Introduction : Cigarette smoking is a potent modifiable risk factor for coronary artery disease (CAD). However, little is known about alterations to prothrombotic state and platelet reactivity early after smoking cessation following percutaneous coronary interventions (PCI). Purpose : We...
Gespeichert in:
| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2023-07, Vol.56 (1), p.75-81 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 81 |
|---|---|
| container_issue | 1 |
| container_start_page | 75 |
| container_title | Journal of thrombosis and thrombolysis |
| container_volume | 56 |
| creator | Ramotowski, Bogumił Undas, Anetta Budaj, Andrzej |
| description | Background/Introduction
: Cigarette smoking is a potent modifiable risk factor for coronary artery disease (CAD). However, little is known about alterations to prothrombotic state and platelet reactivity early after smoking cessation following percutaneous coronary interventions (PCI).
Purpose
: We investigated alterations to platelet reactivity, coagulation and markers of platelet, endothelial, inflammatory and coagulation activation in clopidogrel-treated patients with CAD after PCI before and after smoking cessation.
Methods
: Smoking patients aged 18 years or older at least 30 days after PCI were recruited and encouraged to quit the habit. At baseline and at 30 days, we measured platelet reactivity with VerifyNow system, thrombomodulin, P-selectin, platelet factor 4 (CXCL4/PF4), citrullinated histone H3 (H3cit) and cotinine level.
Results
: Among 117 patients, 84 patients (72%) at a median age of 60.5 years (40 [interquartile range 30–47] pack-years) completed a 30-day follow-up. At day 30, 30 (35.7%) patients stopped smoking with cotinine level |
| doi_str_mv | 10.1007/s11239-023-02819-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10284957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2809546426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-745426a16083444db4317990484d2c91f59db34f804461d3ddd2d905bb5994b53</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEomXgBVggS2xYNODfJF6hqqKAVIkNSOwsJ76ZcevYg-0MmjfhceuZlFJYsLBs634-9x6fqnpJ8FuCcfsuEUKZrDFlZXVE1uJRdUpEy-qW0--PH5xPqmcpXWOMpcT0aXXCWsI60tHT6te5yxDBoK3TGRxkFEEP2e5s3p-hIej1XAo2-DME3oS8AWe1Q9obZP3o9DTpHOIeTTreQEwIdHR7pMciitIUbqxfowFSOmqgHUQ72tLtp82bop6ttx4OvdOky90P4HM8ss-rJ6N2CV7c7avq2-WHrxef6qsvHz9fnF_VA29FLu4Ep40mDe4Y59z0nJG2uOQdN3SQZBTS9IyPHea8IYYZY6iRWPS9kJL3gq2q94vudu4nMMsATm2jLZb2Kmir_q54u1HrsFOk_DmX5YdX1Zs7hRh-zJCymmwawDntIcxJ0Q5LwZsyZkFf_4Nehzn64q9QhRMNlaxQdKGGGFKKMN5PQ7A6JK-W5FVJXh2TVwcfrx76uH_yO-oCsAVIpeTXEP_0_o_sLVVQvWo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2828056293</pqid></control><display><type>article</type><title>Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ramotowski, Bogumił ; Undas, Anetta ; Budaj, Andrzej</creator><creatorcontrib>Ramotowski, Bogumił ; Undas, Anetta ; Budaj, Andrzej</creatorcontrib><description>Background/Introduction
: Cigarette smoking is a potent modifiable risk factor for coronary artery disease (CAD). However, little is known about alterations to prothrombotic state and platelet reactivity early after smoking cessation following percutaneous coronary interventions (PCI).
Purpose
: We investigated alterations to platelet reactivity, coagulation and markers of platelet, endothelial, inflammatory and coagulation activation in clopidogrel-treated patients with CAD after PCI before and after smoking cessation.
Methods
: Smoking patients aged 18 years or older at least 30 days after PCI were recruited and encouraged to quit the habit. At baseline and at 30 days, we measured platelet reactivity with VerifyNow system, thrombomodulin, P-selectin, platelet factor 4 (CXCL4/PF4), citrullinated histone H3 (H3cit) and cotinine level.
Results
: Among 117 patients, 84 patients (72%) at a median age of 60.5 years (40 [interquartile range 30–47] pack-years) completed a 30-day follow-up. At day 30, 30 (35.7%) patients stopped smoking with cotinine level < 50 ng/ml. Baseline characteristics were similar in both groups. In smoking quitters a change in platelet reactivity was larger (Δ platelet reactivity units (PRU) 19 [2, 43] vs. -6 [-32, 37], p = 0.018), along with a change in P-selectin concentration (-11.82 [-23.62, 1.34] vs. 7.19 [-14.24, 17.19] ng/ml, p = 0.005). Positive correlations was noticed between cotinine and both P-selectin ( r = 0.23, p = 0.045) and CXCL4 (r = 0.27, p = 0.02).
Conclusion
: After smoking cessation in CAD patients following PCI an increase in platelet reactivity and a decrease in P-selectin levels were observed. The risk of thrombotic complications post PCI might be paradoxically enhanced among patients who stopped smoking.</description><identifier>ISSN: 1573-742X</identifier><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-023-02819-5</identifier><identifier>PMID: 37138182</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Blood Platelets ; Cardiology ; Cardiovascular disease ; Cigarette smoking ; Citrulline ; Clopidogrel ; Coagulation ; Coronary Artery Disease ; Cotinine ; Drug addiction ; Heart diseases ; Hematology ; Histone H3 ; Histones ; Humans ; Infant ; Inflammation ; Medicine ; Medicine & Public Health ; P-Selectin ; Percutaneous Coronary Intervention - adverse effects ; Platelet Aggregation Inhibitors - therapeutic use ; Platelet factor 4 ; Platelet Function Tests ; Platelets ; Risk factors ; Smoking Cessation</subject><ispartof>Journal of thrombosis and thrombolysis, 2023-07, Vol.56 (1), p.75-81</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-745426a16083444db4317990484d2c91f59db34f804461d3ddd2d905bb5994b53</citedby><cites>FETCH-LOGICAL-c475t-745426a16083444db4317990484d2c91f59db34f804461d3ddd2d905bb5994b53</cites><orcidid>0000-0002-0667-8109 ; 0000-0001-7267-2621 ; 0000-0002-6395-2098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-023-02819-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-023-02819-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37138182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramotowski, Bogumił</creatorcontrib><creatorcontrib>Undas, Anetta</creatorcontrib><creatorcontrib>Budaj, Andrzej</creatorcontrib><title>Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Background/Introduction
: Cigarette smoking is a potent modifiable risk factor for coronary artery disease (CAD). However, little is known about alterations to prothrombotic state and platelet reactivity early after smoking cessation following percutaneous coronary interventions (PCI).
Purpose
: We investigated alterations to platelet reactivity, coagulation and markers of platelet, endothelial, inflammatory and coagulation activation in clopidogrel-treated patients with CAD after PCI before and after smoking cessation.
Methods
: Smoking patients aged 18 years or older at least 30 days after PCI were recruited and encouraged to quit the habit. At baseline and at 30 days, we measured platelet reactivity with VerifyNow system, thrombomodulin, P-selectin, platelet factor 4 (CXCL4/PF4), citrullinated histone H3 (H3cit) and cotinine level.
Results
: Among 117 patients, 84 patients (72%) at a median age of 60.5 years (40 [interquartile range 30–47] pack-years) completed a 30-day follow-up. At day 30, 30 (35.7%) patients stopped smoking with cotinine level < 50 ng/ml. Baseline characteristics were similar in both groups. In smoking quitters a change in platelet reactivity was larger (Δ platelet reactivity units (PRU) 19 [2, 43] vs. -6 [-32, 37], p = 0.018), along with a change in P-selectin concentration (-11.82 [-23.62, 1.34] vs. 7.19 [-14.24, 17.19] ng/ml, p = 0.005). Positive correlations was noticed between cotinine and both P-selectin ( r = 0.23, p = 0.045) and CXCL4 (r = 0.27, p = 0.02).
Conclusion
: After smoking cessation in CAD patients following PCI an increase in platelet reactivity and a decrease in P-selectin levels were observed. The risk of thrombotic complications post PCI might be paradoxically enhanced among patients who stopped smoking.</description><subject>Blood Platelets</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cigarette smoking</subject><subject>Citrulline</subject><subject>Clopidogrel</subject><subject>Coagulation</subject><subject>Coronary Artery Disease</subject><subject>Cotinine</subject><subject>Drug addiction</subject><subject>Heart diseases</subject><subject>Hematology</subject><subject>Histone H3</subject><subject>Histones</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>P-Selectin</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Platelet factor 4</subject><subject>Platelet Function Tests</subject><subject>Platelets</subject><subject>Risk factors</subject><subject>Smoking Cessation</subject><issn>1573-742X</issn><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1DAUhSMEomXgBVggS2xYNODfJF6hqqKAVIkNSOwsJ76ZcevYg-0MmjfhceuZlFJYsLBs634-9x6fqnpJ8FuCcfsuEUKZrDFlZXVE1uJRdUpEy-qW0--PH5xPqmcpXWOMpcT0aXXCWsI60tHT6te5yxDBoK3TGRxkFEEP2e5s3p-hIej1XAo2-DME3oS8AWe1Q9obZP3o9DTpHOIeTTreQEwIdHR7pMciitIUbqxfowFSOmqgHUQ72tLtp82bop6ttx4OvdOky90P4HM8ss-rJ6N2CV7c7avq2-WHrxef6qsvHz9fnF_VA29FLu4Ep40mDe4Y59z0nJG2uOQdN3SQZBTS9IyPHea8IYYZY6iRWPS9kJL3gq2q94vudu4nMMsATm2jLZb2Kmir_q54u1HrsFOk_DmX5YdX1Zs7hRh-zJCymmwawDntIcxJ0Q5LwZsyZkFf_4Nehzn64q9QhRMNlaxQdKGGGFKKMN5PQ7A6JK-W5FVJXh2TVwcfrx76uH_yO-oCsAVIpeTXEP_0_o_sLVVQvWo</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Ramotowski, Bogumił</creator><creator>Undas, Anetta</creator><creator>Budaj, Andrzej</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0667-8109</orcidid><orcidid>https://orcid.org/0000-0001-7267-2621</orcidid><orcidid>https://orcid.org/0000-0002-6395-2098</orcidid></search><sort><creationdate>20230701</creationdate><title>Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration</title><author>Ramotowski, Bogumił ; Undas, Anetta ; Budaj, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-745426a16083444db4317990484d2c91f59db34f804461d3ddd2d905bb5994b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood Platelets</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cigarette smoking</topic><topic>Citrulline</topic><topic>Clopidogrel</topic><topic>Coagulation</topic><topic>Coronary Artery Disease</topic><topic>Cotinine</topic><topic>Drug addiction</topic><topic>Heart diseases</topic><topic>Hematology</topic><topic>Histone H3</topic><topic>Histones</topic><topic>Humans</topic><topic>Infant</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>P-Selectin</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Platelet factor 4</topic><topic>Platelet Function Tests</topic><topic>Platelets</topic><topic>Risk factors</topic><topic>Smoking Cessation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramotowski, Bogumił</creatorcontrib><creatorcontrib>Undas, Anetta</creatorcontrib><creatorcontrib>Budaj, Andrzej</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramotowski, Bogumił</au><au>Undas, Anetta</au><au>Budaj, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>56</volume><issue>1</issue><spage>75</spage><epage>81</epage><pages>75-81</pages><issn>1573-742X</issn><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Background/Introduction
: Cigarette smoking is a potent modifiable risk factor for coronary artery disease (CAD). However, little is known about alterations to prothrombotic state and platelet reactivity early after smoking cessation following percutaneous coronary interventions (PCI).
Purpose
: We investigated alterations to platelet reactivity, coagulation and markers of platelet, endothelial, inflammatory and coagulation activation in clopidogrel-treated patients with CAD after PCI before and after smoking cessation.
Methods
: Smoking patients aged 18 years or older at least 30 days after PCI were recruited and encouraged to quit the habit. At baseline and at 30 days, we measured platelet reactivity with VerifyNow system, thrombomodulin, P-selectin, platelet factor 4 (CXCL4/PF4), citrullinated histone H3 (H3cit) and cotinine level.
Results
: Among 117 patients, 84 patients (72%) at a median age of 60.5 years (40 [interquartile range 30–47] pack-years) completed a 30-day follow-up. At day 30, 30 (35.7%) patients stopped smoking with cotinine level < 50 ng/ml. Baseline characteristics were similar in both groups. In smoking quitters a change in platelet reactivity was larger (Δ platelet reactivity units (PRU) 19 [2, 43] vs. -6 [-32, 37], p = 0.018), along with a change in P-selectin concentration (-11.82 [-23.62, 1.34] vs. 7.19 [-14.24, 17.19] ng/ml, p = 0.005). Positive correlations was noticed between cotinine and both P-selectin ( r = 0.23, p = 0.045) and CXCL4 (r = 0.27, p = 0.02).
Conclusion
: After smoking cessation in CAD patients following PCI an increase in platelet reactivity and a decrease in P-selectin levels were observed. The risk of thrombotic complications post PCI might be paradoxically enhanced among patients who stopped smoking.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37138182</pmid><doi>10.1007/s11239-023-02819-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0667-8109</orcidid><orcidid>https://orcid.org/0000-0001-7267-2621</orcidid><orcidid>https://orcid.org/0000-0002-6395-2098</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1573-742X |
| ispartof | Journal of thrombosis and thrombolysis, 2023-07, Vol.56 (1), p.75-81 |
| issn | 1573-742X 0929-5305 1573-742X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10284957 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Blood Platelets Cardiology Cardiovascular disease Cigarette smoking Citrulline Clopidogrel Coagulation Coronary Artery Disease Cotinine Drug addiction Heart diseases Hematology Histone H3 Histones Humans Infant Inflammation Medicine Medicine & Public Health P-Selectin Percutaneous Coronary Intervention - adverse effects Platelet Aggregation Inhibitors - therapeutic use Platelet factor 4 Platelet Function Tests Platelets Risk factors Smoking Cessation |
| title | Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A33%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20platelet%20reactivity,%20coagulation,%20endothelial%20and%20inflammatory%20markers%20early%20after%20smoking%20cessation%20verified%20with%20cotinine%20plasma%20concentration&rft.jtitle=Journal%20of%20thrombosis%20and%20thrombolysis&rft.au=Ramotowski,%20Bogumi%C5%82&rft.date=2023-07-01&rft.volume=56&rft.issue=1&rft.spage=75&rft.epage=81&rft.pages=75-81&rft.issn=1573-742X&rft.eissn=1573-742X&rft_id=info:doi/10.1007/s11239-023-02819-5&rft_dat=%3Cproquest_pubme%3E2809546426%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2828056293&rft_id=info:pmid/37138182&rfr_iscdi=true |