Signalling by senescent melanocytes hyperactivates hair growth

Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration 1 . Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity. Her...

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Veröffentlicht in:	Nature (London) 2023-06, Vol.618 (7966), p.808-817
Hauptverfasser:	Wang, Xiaojie, Ramos, Raul, Phan, Anne Q., Yamaga, Kosuke, Flesher, Jessica L., Jiang, Shan, Oh, Ji Won, Jin, Suoqin, Jahid, Sohail, Kuan, Chen-Hsiang, Nguyen, Truman Kt, Liang, Heidi Y., Shettigar, Nitish Udupi, Hou, Renzhi, Tran, Kevin H., Nguyen, Andrew, Vu, Kimberly N., Phung, Jennie L., Ingal, Jonard P., Levitt, Katelyn M., Cao, Xiaoling, Liu, Yingzi, Deng, Zhili, Taguchi, Nobuhiko, Scarfone, Vanessa M., Wang, Guangfang, Paolilli, Kara Nicole, Wang, Xiaoyang, Guerrero-Juarez, Christian F., Davis, Ryan T., Greenberg, Elyse Noelani, Ruiz-Vega, Rolando, Vasudeva, Priya, Murad, Rabi, Widyastuti, Lily Halida Putri, Lee, Hye-Lim, McElwee, Kevin J., Gadeau, Alain-Pierre, Lawson, Devon A., Andersen, Bogi, Mortazavi, Ali, Yu, Zhengquan, Nie, Qing, Kunisada, Takahiro, Karin, Michael, Tuckermann, Jan, Esko, Jeffrey D., Ganesan, Anand K., Li, Ji, Plikus, Maksim V.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/31 13/51 14 14/32 38 38/91 631/532/2139 631/532/2438 631/80/509 631/80/86/820 64 64/110 64/60 82 Albinism Animal models Animals CD44 antigen Clusters Congenital diseases Disorders Follicles Genotoxicity Genotype & phenotype Hair Hair - cytology Hair - growth & development Hair cells Hair Follicle - cytology Hair Follicle - physiology Human health and pathology Humanities and Social Sciences Hyaluronan Receptors - metabolism Life Sciences Melanocytes Melanocytes - cytology Melanocytes - metabolism Mice multidisciplinary Mutation Nevus Nevus - metabolism Nevus - pathology Osteopontin Osteopontin - metabolism Science Science (multidisciplinary) Secretome Senescence Signal Transduction Signaling Stem cells Stem Cells - cytology Therapeutic targets Transcriptomes
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