Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer

Triple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSC), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to pr...

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Veröffentlicht in:	Cancer research communications 2023-06, Vol.3 (6), p.1078-1092
Hauptverfasser:	Xie, Xuemei, Chauhan, Gaurav B, Edupuganti, Ramakrishna, Kogawa, Takahiro, Park, Jihyun, Tacam, Moises, Tan, Alex W, Mughees, Mohd, Vidhu, Fnu, Liu, Diane D, Taliaferro, Juliana M, Pitner, Mary Kathryn, Browning, Luke S, Lee, Ju-Hyeon, Shen, Yu, Wang, Jian, Ueno, Naoto T, Krishnamurthy, Savitri, Hortobagyi, Gabriel N, Tripathy, Debu, Van Laere, Steven J, Bartholomeusz, Geoffrey, Dalby, Kevin N, Bartholomeusz, Chandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Cancer Carcinogenesis Cell Proliferation - physiology Humans Leucine Zippers Mice Mice, Nude Neoplasm Recurrence, Local Oncogenes & Tumor Suppressors Progression, Invasion & Metastasis Protein Serine-Threonine Kinases - genetics Stem Cell Biology Triple Negative Breast Neoplasms - genetics
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