Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway

Monocyte activation plays an important role in diabetic complications such as diabetic retinopathy (DR). However, the regulation of monocyte activation in diabetes remains elusive. Fenofibrate, an agonist of peroxisome proliferator-activated receptor-α (PPARα), has shown robust therapeutic effects o...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-07, Vol.72 (7), p.958-972
Hauptverfasser:	Dong, Lijie, Cheng, Rui, Ma, Xiang, Liang, Wentao, Hong, Yaru, Li, Hui, Zhou, Kelu, Du, Yanhong, Takahashi, Yusuke, Zhang, Xiaomin, Li, Xiao-Rong, Ma, Jian-Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Cell activation Complications Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetic Retinopathy - metabolism Down-regulation Fenofibrate Fenofibrate - pharmacology Fenofibrate - therapeutic use Glycolysis Metabolic rate Mitochondrial DNA Monocytes Monocytes - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Peroxisome proliferator-activated receptors PPAR alpha - genetics PPAR alpha - metabolism Retinopathy
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