Adult form of Leigh's disease: a clinico pathological case with CT scan examination
The clinical and pathological findings of a 31-year-old woman, in whom the diagnosis of Leigh's disease was made, are reported. CT scan examination with contrast enhancement showed symmetrical areas of low density, in both thalami, anterior limbs of internal capsules and corpus callosum. Longst...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1984-11, Vol.47 (11), p.1211-1215 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Gray, F Louarn, F Gherardi, R Eizenbaum, J F Marsault, C |
| description | The clinical and pathological findings of a 31-year-old woman, in whom the diagnosis of Leigh's disease was made, are reported. CT scan examination with contrast enhancement showed symmetrical areas of low density, in both thalami, anterior limbs of internal capsules and corpus callosum. Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary proliferation. The neurons were spared. In the basal ganglia, internal capsules and corpus callosum, these lesions were more recent and consisted of focal necrosis, perivascular oedema and few lymphocytic perivascular cuffings. |
| doi_str_mv | 10.1136/jnnp.47.11.1211 |
| format | Article |
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CT scan examination with contrast enhancement showed symmetrical areas of low density, in both thalami, anterior limbs of internal capsules and corpus callosum. Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary proliferation. The neurons were spared. In the basal ganglia, internal capsules and corpus callosum, these lesions were more recent and consisted of focal necrosis, perivascular oedema and few lymphocytic perivascular cuffings.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.47.11.1211</identifier><identifier>PMID: 6502179</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Biological and medical sciences ; Brain - pathology ; Brain Diseases, Metabolic - pathology ; Female ; Humans ; Leigh Disease - diagnosis ; Leigh Disease - pathology ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Tomography, X-Ray Computed</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1984-11, Vol.47 (11), p.1211-1215</ispartof><rights>1985 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Nov 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b518t-321449cd2aee5fda7f217609bf31dc372fe409985f0632cea3f382d59a4e28983</citedby><cites>FETCH-LOGICAL-b518t-321449cd2aee5fda7f217609bf31dc372fe409985f0632cea3f382d59a4e28983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1028088/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1028088/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9048153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6502179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, F</creatorcontrib><creatorcontrib>Louarn, F</creatorcontrib><creatorcontrib>Gherardi, R</creatorcontrib><creatorcontrib>Eizenbaum, J F</creatorcontrib><creatorcontrib>Marsault, C</creatorcontrib><title>Adult form of Leigh's disease: a clinico pathological case with CT scan examination</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>The clinical and pathological findings of a 31-year-old woman, in whom the diagnosis of Leigh's disease was made, are reported. CT scan examination with contrast enhancement showed symmetrical areas of low density, in both thalami, anterior limbs of internal capsules and corpus callosum. Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary proliferation. The neurons were spared. In the basal ganglia, internal capsules and corpus callosum, these lesions were more recent and consisted of focal necrosis, perivascular oedema and few lymphocytic perivascular cuffings.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Diseases, Metabolic - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Leigh Disease - diagnosis</subject><subject>Leigh Disease - pathology</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Tomography, X-Ray Computed</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd2LEzEUxYMoa1199kkIKArCdPMxM0l8ENbiF5RV2NX1LaSZpE3NJDWZ0fW_N2NLUV_MS7icX-49NweAhxjNMabt2TaE3bxmpZhjgvEtMMN1yytK0ZfbYIYQIRVFDboL7uW8RdPh4gSctA0imIkZuDzvRj9AG1MPo4VL49abZxl2LhuVzQuooPYuOB3hTg2b6OPaaeWhLiL84YYNXFzBrFWA5kb1LqjBxXAf3LHKZ_PgcJ-CT29eXy3eVcsPb98vzpfVqsF8qCjBdS10R5Qxje0Us8VSi8TKUtxpyog1NRKCNxa1lGijqKWcdI1QtSFccHoKXu777sZVbzptwpCUl7vkepV-yqic_FsJbiPX8bvEiHDEpwZPDw1S_DaaPMjeZW28V8HEMUvWMNbS35Me_wNu45hCWU5ixghvEa1xoc72lE4x52Ts0QpGckpLTmnJmpVCTmmVF4_-3ODIH-Ip-pODrsone5tU0C4fMYFqjhtasGqPuTyYm6Os0lfZMsoaefF5IdtL8fEVubiW14V_vudX_fa_Hn8BMGO5yw</recordid><startdate>19841101</startdate><enddate>19841101</enddate><creator>Gray, F</creator><creator>Louarn, F</creator><creator>Gherardi, R</creator><creator>Eizenbaum, J F</creator><creator>Marsault, C</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19841101</creationdate><title>Adult form of Leigh's disease: a clinico pathological case with CT scan examination</title><author>Gray, F ; Louarn, F ; Gherardi, R ; Eizenbaum, J F ; Marsault, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b518t-321449cd2aee5fda7f217609bf31dc372fe409985f0632cea3f382d59a4e28983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain Diseases, Metabolic - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Leigh Disease - diagnosis</topic><topic>Leigh Disease - pathology</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gray, F</creatorcontrib><creatorcontrib>Louarn, F</creatorcontrib><creatorcontrib>Gherardi, R</creatorcontrib><creatorcontrib>Eizenbaum, J F</creatorcontrib><creatorcontrib>Marsault, C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gray, F</au><au>Louarn, F</au><au>Gherardi, R</au><au>Eizenbaum, J F</au><au>Marsault, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult form of Leigh's disease: a clinico pathological case with CT scan examination</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1984-11-01</date><risdate>1984</risdate><volume>47</volume><issue>11</issue><spage>1211</spage><epage>1215</epage><pages>1211-1215</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>The clinical and pathological findings of a 31-year-old woman, in whom the diagnosis of Leigh's disease was made, are reported. CT scan examination with contrast enhancement showed symmetrical areas of low density, in both thalami, anterior limbs of internal capsules and corpus callosum. Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary proliferation. The neurons were spared. In the basal ganglia, internal capsules and corpus callosum, these lesions were more recent and consisted of focal necrosis, perivascular oedema and few lymphocytic perivascular cuffings.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>6502179</pmid><doi>10.1136/jnnp.47.11.1211</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 1984-11, Vol.47 (11), p.1211-1215 |
| issn | 0022-3050 1468-330X |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Brain - pathology Brain Diseases, Metabolic - pathology Female Humans Leigh Disease - diagnosis Leigh Disease - pathology Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Tomography, X-Ray Computed |
| title | Adult form of Leigh's disease: a clinico pathological case with CT scan examination |
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