Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens
A 35-day trial was set to explore the effects of different dietary zinc sources on growth, insulin-like growth factor I (IGF-I) mRNA expression, meat quality, immune response, antioxidant activity, and immunohistochemistry of nuclear factor kappa B (NF-κ7B) of broiler chickens. Ross 308 broiler chic...
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| Veröffentlicht in: | Biological trace element research 2023-08, Vol.201 (8), p.4062-4078 |
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| creator | Alian, Heba A. Samy, Hayam M. Ibrahim, Mohammed T. Yusuf, Mohamed S. Mahmoud, Manal M. A. |
| description | A 35-day trial was set to explore the effects of different dietary zinc sources on growth, insulin-like growth factor I (IGF-I) mRNA expression, meat quality, immune response, antioxidant activity, and immunohistochemistry of nuclear factor kappa B (NF-κ7B) of broiler chickens. Ross 308 broiler chicks (
n
= 156) were randomly assigned into four experimental groups. The G1 received the basal control diet without zinc supplementation; the G2, G3, and G4 were supplemented with zinc oxide, zinc lysine, and nano zinc oxide, respectively, at a level of 40 mg Zn/kg diet. The data revealed that nano zinc oxide linearly improved the overall growth performance parameters. Nano zinc oxide linearly elevated (
P
|
| doi_str_mv | 10.1007/s12011-022-03494-y |
| format | Article |
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n
= 156) were randomly assigned into four experimental groups. The G1 received the basal control diet without zinc supplementation; the G2, G3, and G4 were supplemented with zinc oxide, zinc lysine, and nano zinc oxide, respectively, at a level of 40 mg Zn/kg diet. The data revealed that nano zinc oxide linearly improved the overall growth performance parameters. Nano zinc oxide linearly elevated (
P
< 0.001) mRNA expression of IGF-I followed by G3. The pH value of breast muscle in G4 shows a linearly decreasing value (
P
< 0.001). Also, the linearly highest expressible release volume percentage and lightness (L*) value with the lowest redness (a*) value (
P
< 0.05) were recorded in G4 and G3. A numerical increase in the total antibody titer was recorded on the 35
th
day in the G3 and G4. A numerical elevation in the superoxide dismutase (SOD) and a numerical reduction in the serum malondialdehyde (MDA) were recorded in the G4. The section of the liver from G4 revealed significantly very low expression of NF-κB staining. It is concluded that nano zinc oxide is considered the more trending zinc source. It had no negative effects on the health status and can be used in broiler diet premix.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-022-03494-y</identifier><identifier>PMID: 36434422</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal Feed - analysis ; Animals ; Antibodies ; antioxidant activity ; Antioxidants - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; blood serum ; Breast muscle ; Chickens ; Chickens - metabolism ; Defence mechanisms ; Diet ; Diet - veterinary ; dietary mineral supplements ; Dietary Supplements ; Gene expression ; Growth factors ; growth performance ; health status ; Humerus ; Immune response ; Immune system ; Immunity ; Immunohistochemistry ; Insulin ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Insulin-like growth factors ; Life Sciences ; liver ; Lysine ; Malondialdehyde ; Meat ; Meat - analysis ; Meat quality ; NF-kappa B - metabolism ; NF-κB protein ; Nutrition ; Oncology ; Oxidative Stress ; Performance enhancement ; Poultry ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Serum ; Superoxide dismutase ; transcription factor NF-kappa B ; Zinc ; Zinc - pharmacology ; Zinc oxide ; Zinc Oxide - pharmacology ; Zinc oxides</subject><ispartof>Biological trace element research, 2023-08, Vol.201 (8), p.4062-4078</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-c6b881bff90cd549fbec3297ae2aca72454218b078878446c0701b4f837994e43</citedby><cites>FETCH-LOGICAL-c508t-c6b881bff90cd549fbec3297ae2aca72454218b078878446c0701b4f837994e43</cites><orcidid>0000-0002-7563-2016</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-022-03494-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-022-03494-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36434422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alian, Heba A.</creatorcontrib><creatorcontrib>Samy, Hayam M.</creatorcontrib><creatorcontrib>Ibrahim, Mohammed T.</creatorcontrib><creatorcontrib>Yusuf, Mohamed S.</creatorcontrib><creatorcontrib>Mahmoud, Manal M. A.</creatorcontrib><title>Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>A 35-day trial was set to explore the effects of different dietary zinc sources on growth, insulin-like growth factor I (IGF-I) mRNA expression, meat quality, immune response, antioxidant activity, and immunohistochemistry of nuclear factor kappa B (NF-κ7B) of broiler chickens. Ross 308 broiler chicks (
n
= 156) were randomly assigned into four experimental groups. The G1 received the basal control diet without zinc supplementation; the G2, G3, and G4 were supplemented with zinc oxide, zinc lysine, and nano zinc oxide, respectively, at a level of 40 mg Zn/kg diet. The data revealed that nano zinc oxide linearly improved the overall growth performance parameters. Nano zinc oxide linearly elevated (
P
< 0.001) mRNA expression of IGF-I followed by G3. The pH value of breast muscle in G4 shows a linearly decreasing value (
P
< 0.001). Also, the linearly highest expressible release volume percentage and lightness (L*) value with the lowest redness (a*) value (
P
< 0.05) were recorded in G4 and G3. A numerical increase in the total antibody titer was recorded on the 35
th
day in the G3 and G4. A numerical elevation in the superoxide dismutase (SOD) and a numerical reduction in the serum malondialdehyde (MDA) were recorded in the G4. The section of the liver from G4 revealed significantly very low expression of NF-κB staining. It is concluded that nano zinc oxide is considered the more trending zinc source. It had no negative effects on the health status and can be used in broiler diet premix.</description><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Antibodies</subject><subject>antioxidant activity</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>blood serum</subject><subject>Breast muscle</subject><subject>Chickens</subject><subject>Chickens - metabolism</subject><subject>Defence mechanisms</subject><subject>Diet</subject><subject>Diet - veterinary</subject><subject>dietary mineral supplements</subject><subject>Dietary Supplements</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>growth performance</subject><subject>health status</subject><subject>Humerus</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunohistochemistry</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factors</subject><subject>Life Sciences</subject><subject>liver</subject><subject>Lysine</subject><subject>Malondialdehyde</subject><subject>Meat</subject><subject>Meat - analysis</subject><subject>Meat quality</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative Stress</subject><subject>Performance enhancement</subject><subject>Poultry</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Serum</subject><subject>Superoxide dismutase</subject><subject>transcription factor NF-kappa B</subject><subject>Zinc</subject><subject>Zinc - pharmacology</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - pharmacology</subject><subject>Zinc oxides</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks1uEzEUhUcIREvhBVggS2xYZMB_Mx6vUBo1baSSQoENG8vj3GlcZuxgz0TNq_UheCacpJSfBazu4nz3XB_rZNlzgl8TjMWbSCgmJMeU5phxyfPNg-yQFIXMsaD4YXaISclyLit-kD2J8RpjIqhkj7MDVnLGOaWH2e1cO4--WGfQxY1dAJp1q-DXENF7CI0PnXYGRmh2Os1nqLucj9HJzSpAjNa7EXoHukcfBt3afjNC2i3Q2dBB0G2y6QYH6BLiyrsIO23ctrC2uk_m21u6t2tAH_ut206fT_Pvt8f7Vb-0sfdmCV2aYYN8g46Dty0ENFla8xVcfJo9anQb4dndPMo-T08-Tc7y84vT2WR8npsCV31uyrqqSN00EptFwWVTg2FUCg1UGy0oLzglVY1FVYmK89JggUnNm4oJKTlwdpS93fuuhrqDhQHXp4RqFWynw0Z5bdWfirNLdeXXimAqZCHK5PDqziH4bwPEXqVUBtpWO_BDVIwUjOJScPxflCaowLIsZUJf_oVe-yG49BWKVlSwUgjJEkX3lAk-xgDN_cMJVtsaqX2NVKqR2tVIbdLSi98j36_87E0C2B6ISXJXEH7d_oftDwQ_1bQ</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Alian, Heba A.</creator><creator>Samy, Hayam M.</creator><creator>Ibrahim, Mohammed T.</creator><creator>Yusuf, Mohamed S.</creator><creator>Mahmoud, Manal M. 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A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-c6b881bff90cd549fbec3297ae2aca72454218b078878446c0701b4f837994e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Antibodies</topic><topic>antioxidant activity</topic><topic>Antioxidants - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>blood serum</topic><topic>Breast muscle</topic><topic>Chickens</topic><topic>Chickens - metabolism</topic><topic>Defence mechanisms</topic><topic>Diet</topic><topic>Diet - veterinary</topic><topic>dietary mineral supplements</topic><topic>Dietary Supplements</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>growth performance</topic><topic>health status</topic><topic>Humerus</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunohistochemistry</topic><topic>Insulin</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factors</topic><topic>Life Sciences</topic><topic>liver</topic><topic>Lysine</topic><topic>Malondialdehyde</topic><topic>Meat</topic><topic>Meat - analysis</topic><topic>Meat quality</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Oxidative Stress</topic><topic>Performance enhancement</topic><topic>Poultry</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Serum</topic><topic>Superoxide dismutase</topic><topic>transcription factor NF-kappa B</topic><topic>Zinc</topic><topic>Zinc - pharmacology</topic><topic>Zinc oxide</topic><topic>Zinc Oxide - pharmacology</topic><topic>Zinc oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alian, Heba A.</creatorcontrib><creatorcontrib>Samy, Hayam M.</creatorcontrib><creatorcontrib>Ibrahim, Mohammed T.</creatorcontrib><creatorcontrib>Yusuf, Mohamed S.</creatorcontrib><creatorcontrib>Mahmoud, Manal M. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>201</volume><issue>8</issue><spage>4062</spage><epage>4078</epage><pages>4062-4078</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>A 35-day trial was set to explore the effects of different dietary zinc sources on growth, insulin-like growth factor I (IGF-I) mRNA expression, meat quality, immune response, antioxidant activity, and immunohistochemistry of nuclear factor kappa B (NF-κ7B) of broiler chickens. Ross 308 broiler chicks (
n
= 156) were randomly assigned into four experimental groups. The G1 received the basal control diet without zinc supplementation; the G2, G3, and G4 were supplemented with zinc oxide, zinc lysine, and nano zinc oxide, respectively, at a level of 40 mg Zn/kg diet. The data revealed that nano zinc oxide linearly improved the overall growth performance parameters. Nano zinc oxide linearly elevated (
P
< 0.001) mRNA expression of IGF-I followed by G3. The pH value of breast muscle in G4 shows a linearly decreasing value (
P
< 0.001). Also, the linearly highest expressible release volume percentage and lightness (L*) value with the lowest redness (a*) value (
P
< 0.05) were recorded in G4 and G3. A numerical increase in the total antibody titer was recorded on the 35
th
day in the G3 and G4. A numerical elevation in the superoxide dismutase (SOD) and a numerical reduction in the serum malondialdehyde (MDA) were recorded in the G4. The section of the liver from G4 revealed significantly very low expression of NF-κB staining. It is concluded that nano zinc oxide is considered the more trending zinc source. It had no negative effects on the health status and can be used in broiler diet premix.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36434422</pmid><doi>10.1007/s12011-022-03494-y</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-7563-2016</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological trace element research, 2023-08, Vol.201 (8), p.4062-4078 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animal Feed - analysis Animals Antibodies antioxidant activity Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biotechnology blood serum Breast muscle Chickens Chickens - metabolism Defence mechanisms Diet Diet - veterinary dietary mineral supplements Dietary Supplements Gene expression Growth factors growth performance health status Humerus Immune response Immune system Immunity Immunohistochemistry Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Life Sciences liver Lysine Malondialdehyde Meat Meat - analysis Meat quality NF-kappa B - metabolism NF-κB protein Nutrition Oncology Oxidative Stress Performance enhancement Poultry RNA, Messenger - genetics RNA, Messenger - metabolism Serum Superoxide dismutase transcription factor NF-kappa B Zinc Zinc - pharmacology Zinc oxide Zinc Oxide - pharmacology Zinc oxides |
| title | Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens |
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