HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms

HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanisms. Herewith we aimed to gain pathophysiological insights and fuel oppo...

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Veröffentlicht in:	EBioMedicine 2023-07, Vol.93, p.104655-104655, Article 104655
Hauptverfasser:	Petersen, Teun B., de Bakker, Marie, Asselbergs, Folkert W., Harakalova, Magdalena, Akkerhuis, K. Martijn, Brugts, Jasper J., van Ramshorst, Jan, Lumbers, R. Thomas, Ostroff, Rachel M., Katsikis, Peter D., van der Spek, Peter J., Umans, Victor A., Boersma, Eric, Rizopoulos, Dimitris, Kardys, Isabella
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Heart Failure Phenotypes Proteomics Unsupervised machine learning
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