Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years
To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques. Studies from the "PubMed", "Embase", and "BVS" databases were analyzed. The articles selected in the review included: cohort and...
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| Veröffentlicht in: | JBRA assisted reproduction 2023, Vol.27 (2), p.282-291 |
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| container_title | JBRA assisted reproduction |
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| creator | Lourenço, Mayara Lobato Moura, Gabriel Acácio de Rocha, Yasmim Mendes Rodrigues, João Pedro Viana Monteiro, Paula Bruno |
| description | To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques.
Studies from the "PubMed", "Embase", and "BVS" databases were analyzed.
The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases.
Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques.
In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate.
Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques. |
| doi_str_mv | 10.5935/1518-0557.20220057 |
| format | Article |
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Studies from the "PubMed", "Embase", and "BVS" databases were analyzed.
The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases.
Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques.
In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate.
Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques.</description><identifier>ISSN: 1518-0557</identifier><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20220057</identifier><identifier>PMID: 36749810</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Age ; Clinical outcomes ; DNA damage ; Embryos ; Fertility ; Flow cytometry ; In vitro fertilization ; Infertility ; Motility ; Review ; Sperm ; Systematic review</subject><ispartof>JBRA assisted reproduction, 2023, Vol.27 (2), p.282-291</ispartof><rights>2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-9dd600a63d8c78b3bfba9c6bbe05049ca7f1e569d3979a68698abdd03b9ad8603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279435/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279435/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36749810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lourenço, Mayara Lobato</creatorcontrib><creatorcontrib>Moura, Gabriel Acácio de</creatorcontrib><creatorcontrib>Rocha, Yasmim Mendes</creatorcontrib><creatorcontrib>Rodrigues, João Pedro Viana</creatorcontrib><creatorcontrib>Monteiro, Paula Bruno</creatorcontrib><title>Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques.
Studies from the "PubMed", "Embase", and "BVS" databases were analyzed.
The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases.
Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques.
In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate.
Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques.</description><subject>Age</subject><subject>Clinical outcomes</subject><subject>DNA damage</subject><subject>Embryos</subject><subject>Fertility</subject><subject>Flow cytometry</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Motility</subject><subject>Review</subject><subject>Sperm</subject><subject>Systematic review</subject><issn>1518-0557</issn><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUFrFTEUhYMottT-ARcScOPm1ZvJzCRxI6W2Wii60XW4k2T6UmYmY5J58n6C_9qMbR9VCCTcfOdwD4eQ1wzOGsWb96xhcgNNI84qqCqARjwjx4fh8yfvI3Ka0h0AMMUqXsNLcsRbUSvJ4Jj8vh5nNJmGnqbZxZF--npO-4i3o5syZh8mWk7eOmoGP3mDAw1LNmF0qwRT8ik7S6ObY7CL-SvIzmwn_3Nx6QNFmvaFGIuVKdTOu1-rcDUcMGXa-52je4cxvSIvehySO324T8iPq8vvF182N98-X1-c32xMzVneKGtbAGy5lUbIjnd9h8q0XeeggVoZFD1zTassV0JhK1slsbMWeKfQyhb4Cfl47zsv3eisKTkjDnqOfsS41wG9_vdn8lt9G3aaQSVUzZvi8O7BIYY1ZdajT8YNA04uLElXQtS1Kjvwgr79D70LS5xKPl1JzoQExupCVfeUiSGl6PrDNgz02rZey9Rrmfqx7SJ68zTHQfLYLf8DAGKnzA</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Lourenço, Mayara Lobato</creator><creator>Moura, Gabriel Acácio de</creator><creator>Rocha, Yasmim Mendes</creator><creator>Rodrigues, João Pedro Viana</creator><creator>Monteiro, Paula Bruno</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years</title><author>Lourenço, Mayara Lobato ; 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Studies from the "PubMed", "Embase", and "BVS" databases were analyzed.
The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases.
Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques.
In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate.
Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>36749810</pmid><doi>10.5935/1518-0557.20220057</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | JBRA assisted reproduction, 2023, Vol.27 (2), p.282-291 |
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| subjects | Age Clinical outcomes DNA damage Embryos Fertility Flow cytometry In vitro fertilization Infertility Motility Review Sperm Systematic review |
| title | Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years |
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