Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function

•Bispecific CAR T cells circumvent outgrowth of antigen-negative tumor cells in vivo.•Tandem and bicistronic CARs have reduced sensitivity to single-antigen tumor cells because of compromised antigen binding and signaling. [Display omitted] Therapy with CD19-directed chimeric antigen receptor (CAR)...

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Veröffentlicht in:	Blood advances 2023-06, Vol.7 (12), p.2718-2730
Hauptverfasser:	Leung, Isabel, Templeton, Megan L., Lo, Yun, Rajan, Anusha, Stull, Sylvia M., Garrison, Sarah M., Salter, Alexander I., Smythe, Kimberly S., Correnti, Colin E., Srivastava, Shivani, Yeung, Cecilia C. S., Riddell, Stanley R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism B-Lymphocytes - metabolism Humans Immunobiology and Immunotherapy Immunotherapy, Adoptive Neoplasms - metabolism Receptors, Chimeric Antigen - metabolism T-Lymphocytes
Online-Zugang:	Volltext
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