Characterization of the human and mouse WRN 3'-->5' exonuclease

Werner's syndrome (WS) is an autosomal recessive disorder in humans characterized by the premature development of a partial array of age-associated pathologies. WRN, the gene defective in WS, encodes a 1432 amino acid protein (hWRN) with intrinsic 3'-->5' DNA helicase activity. We...

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Veröffentlicht in:	Nucleic acids research 2000-06, Vol.28 (12), p.2396-2405
Hauptverfasser:	Huang, S, Beresten, S, Li, B, Oshima, J, Ellis, N A, Campisi, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - metabolism Exodeoxyribonuclease V Exodeoxyribonucleases - metabolism Humans Mice Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism RecQ Helicases Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity Werner Syndrome - enzymology Werner Syndrome - genetics Werner Syndrome Helicase
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