Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions

•Few studies have evaluated gene-environment interaction in the risk of autism spectrum disorder (ASD).•Single nucleotide polymorphism (SNPs) in relevant genes (e.g. immune, inflammatory, serotonin) were analyzed.•Two experienced industrial hygienists estimated parental occupational exposure to solvents.•Additive and multiplicative gene-environment interactions between SNPs and parental solventexposure were evaluated.•SNP x solvent interaction is associated with higher rates of ASD compared to the SNP alone or solvent exposure alone.