Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells

Sestrins (SESN1-3) act as proximal sensors in leucine-induced activation of the protein kinase mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), a key regulator of cell growth and metabolism. In the present study, the hypothesis that SESNs also mediate glucose-induced activation of mTORC...

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Veröffentlicht in:	The Journal of nutrition 2023-04, Vol.153 (4), p.988-998
Hauptverfasser:	Roberson, Paul A., Kincheloe, Gregory N., Welles, Jaclyn E., Xu, Dandan, Sam-Clarke, Mahalia, MacLean, Paul S., Lang, Charles H., Jefferson, Leonard S., Kimball, Scot R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemical, Molecular, and Genetic Mechanisms in Nutrition Cell activation Cells Glucose Glucose - pharmacology HEK293 Cells Hexokinase Hexokinase - metabolism Hexokinase - pharmacology Humans Immunoprecipitation Kinases Leucine Leucine - pharmacology Liver cancer Mechanistic Target of Rapamycin Complex 1 - metabolism Metabolism mTORC1 nutrient signaling Proteins Rapamycin Rats Sensors Sestrins - metabolism Signal Transduction Skeletal muscle Tibialis anterior muscle TOR protein TOR Serine-Threonine Kinases - metabolism Variance analysis
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