Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age
Abnormal tau, a hallmark Alzheimer's disease (AD) pathology, may appear in the locus coeruleus (LC) decades before AD symptom onset. Reports of subjective cognitive decline are also often present prior to formal diagnosis. Yet, the relationship between LC structural integrity and subjective cog...
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| Veröffentlicht in: | Journal of the International Neuropsychological Society 2023-10, Vol.29 (8), p.763-774 |
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| creator | Bell, Tyler Reed Elman, Jeremy A. Beck, Asad Fennema-Notestine, Christine Gustavson, Daniel E. Hagler, Donald J. Jack, Amy J. Lyons, Michael J. Puckett, Olivia K. Toomey, Rosemary Franz, Carol E. Kremen, William S. |
| description | Abnormal tau, a hallmark Alzheimer's disease (AD) pathology, may appear in the locus coeruleus (LC) decades before AD symptom onset. Reports of subjective cognitive decline are also often present prior to formal diagnosis. Yet, the relationship between LC structural integrity and subjective cognitive decline has remained unexplored. Here, we aimed to explore these potential associations.
We examined 381 community-dwelling men (mean age = 67.58;
= 2.62) in the Vietnam Era Twin Study of Aging who underwent LC-sensitive magnetic resonance imaging and completed the Everyday Cognition scale to measure subjective cognitive decline along with their selected informants. Mixed models examined the associations between rostral-middle and caudal LC integrity and subjective cognitive decline after adjusting for depressive symptoms, physical morbidities, and family. Models also adjusted for current objective cognitive performance and objective cognitive decline to explore attenuation.
For participant ratings, lower rostral-middle LC contrast to noise ratio (LC
) was associated with significantly greater subjective decline in memory, executive function, and visuospatial abilities. For informant ratings, lower rostral-middle LC
was associated with significantly greater subjective decline in memory only. Associations remained after adjusting for current objective cognition and objective cognitive decline in respective domains.
Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology. |
| doi_str_mv | 10.1017/S1355617722000881 |
| format | Article |
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We examined 381 community-dwelling men (mean age = 67.58;
= 2.62) in the Vietnam Era Twin Study of Aging who underwent LC-sensitive magnetic resonance imaging and completed the Everyday Cognition scale to measure subjective cognitive decline along with their selected informants. Mixed models examined the associations between rostral-middle and caudal LC integrity and subjective cognitive decline after adjusting for depressive symptoms, physical morbidities, and family. Models also adjusted for current objective cognitive performance and objective cognitive decline to explore attenuation.
For participant ratings, lower rostral-middle LC contrast to noise ratio (LC
) was associated with significantly greater subjective decline in memory, executive function, and visuospatial abilities. For informant ratings, lower rostral-middle LC
was associated with significantly greater subjective decline in memory only. Associations remained after adjusting for current objective cognition and objective cognitive decline in respective domains.
Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.</description><identifier>ISSN: 1355-6177</identifier><identifier>ISSN: 1469-7661</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617722000881</identifier><identifier>PMID: 36524301</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Aged ; Aging ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Arousal ; Biomarkers ; Cognition ; Cognitive ability ; Cognitive Dysfunction ; Dementia ; Executive function ; Humans ; Information processing ; Investigations ; Locus coeruleus ; Locus Coeruleus - diagnostic imaging ; Locus Coeruleus - pathology ; Magnetic resonance imaging ; Male ; Medical imaging ; Memory ; Neurodegenerative diseases ; Neuroimaging ; Older people ; Pathology ; Spatial memory ; Tau protein ; Twins ; Visual perception</subject><ispartof>Journal of the International Neuropsychological Society, 2023-10, Vol.29 (8), p.763-774</ispartof><rights>Copyright © INS. Published by Cambridge University Press, 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-ab95c7a57d43f3146f9c5896f8c22e5a25779fe03fa87f9fa4f73b367c0ed3103</citedby><cites>FETCH-LOGICAL-c472t-ab95c7a57d43f3146f9c5896f8c22e5a25779fe03fa87f9fa4f73b367c0ed3103</cites><orcidid>0000-0001-5702-5995 ; 0000-0002-1470-4928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617722000881/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,778,782,883,27911,27912,55615</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36524301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bell, Tyler Reed</creatorcontrib><creatorcontrib>Elman, Jeremy A.</creatorcontrib><creatorcontrib>Beck, Asad</creatorcontrib><creatorcontrib>Fennema-Notestine, Christine</creatorcontrib><creatorcontrib>Gustavson, Daniel E.</creatorcontrib><creatorcontrib>Hagler, Donald J.</creatorcontrib><creatorcontrib>Jack, Amy J.</creatorcontrib><creatorcontrib>Lyons, Michael J.</creatorcontrib><creatorcontrib>Puckett, Olivia K.</creatorcontrib><creatorcontrib>Toomey, Rosemary</creatorcontrib><creatorcontrib>Franz, Carol E.</creatorcontrib><creatorcontrib>Kremen, William S.</creatorcontrib><title>Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>Abnormal tau, a hallmark Alzheimer's disease (AD) pathology, may appear in the locus coeruleus (LC) decades before AD symptom onset. Reports of subjective cognitive decline are also often present prior to formal diagnosis. Yet, the relationship between LC structural integrity and subjective cognitive decline has remained unexplored. Here, we aimed to explore these potential associations.
We examined 381 community-dwelling men (mean age = 67.58;
= 2.62) in the Vietnam Era Twin Study of Aging who underwent LC-sensitive magnetic resonance imaging and completed the Everyday Cognition scale to measure subjective cognitive decline along with their selected informants. Mixed models examined the associations between rostral-middle and caudal LC integrity and subjective cognitive decline after adjusting for depressive symptoms, physical morbidities, and family. Models also adjusted for current objective cognitive performance and objective cognitive decline to explore attenuation.
For participant ratings, lower rostral-middle LC contrast to noise ratio (LC
) was associated with significantly greater subjective decline in memory, executive function, and visuospatial abilities. For informant ratings, lower rostral-middle LC
was associated with significantly greater subjective decline in memory only. Associations remained after adjusting for current objective cognition and objective cognitive decline in respective domains.
Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.</description><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Arousal</subject><subject>Biomarkers</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction</subject><subject>Dementia</subject><subject>Executive function</subject><subject>Humans</subject><subject>Information processing</subject><subject>Investigations</subject><subject>Locus coeruleus</subject><subject>Locus Coeruleus - diagnostic imaging</subject><subject>Locus Coeruleus - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Older people</subject><subject>Pathology</subject><subject>Spatial memory</subject><subject>Tau protein</subject><subject>Twins</subject><subject>Visual perception</subject><issn>1355-6177</issn><issn>1469-7661</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9rFTEUxYMotlY_QDcy4Kab0fyZJJOVSGlVKAjabtyETHIz5pGZtMlM4X178-yztYqrHLi_e3LPvQgdE_yWYCLffSOMc0GkpBRj3PfkCToknVCtFII8rbqW2139AL0oZYMxYQTj5-iACU47hskh-v41lSWb2E7BuQhNTHYtjU2Q1whVhXmBMYdl25jZNWUdNmCXcAsVGefwSzmwMcxQ0QZMjtsmRdeYEV6iZ97EAq_27xG6Oj-7PP3UXnz5-Pn0w0VrO0mX1gyKW2m4dB3zrI7vleW9Er63lAI3lEupPGDmTS-98qbzkg1MSIvB1TzsCL2_871ehwmchXkXSF_nMJm81ckE_bgyhx96TLeaYFo3p2h1ONk75HSzQln0FIqFGM0MaS2aSs55jyURFX3zF7pJa55rPk17wTqlGO8qRe4om1MpGfz9NATr3en0P6erPa__jHHf8ftWFWB7UzMNObgRHv7-v-1P5imkQw</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Bell, Tyler Reed</creator><creator>Elman, Jeremy A.</creator><creator>Beck, Asad</creator><creator>Fennema-Notestine, Christine</creator><creator>Gustavson, Daniel E.</creator><creator>Hagler, Donald J.</creator><creator>Jack, Amy J.</creator><creator>Lyons, Michael J.</creator><creator>Puckett, Olivia K.</creator><creator>Toomey, Rosemary</creator><creator>Franz, Carol E.</creator><creator>Kremen, William S.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5702-5995</orcidid><orcidid>https://orcid.org/0000-0002-1470-4928</orcidid></search><sort><creationdate>20231001</creationdate><title>Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age</title><author>Bell, Tyler Reed ; Elman, Jeremy A. ; Beck, Asad ; Fennema-Notestine, Christine ; Gustavson, Daniel E. ; Hagler, Donald J. ; Jack, Amy J. ; Lyons, Michael J. ; Puckett, Olivia K. ; Toomey, Rosemary ; Franz, Carol E. ; Kremen, William S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-ab95c7a57d43f3146f9c5896f8c22e5a25779fe03fa87f9fa4f73b367c0ed3103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Arousal</topic><topic>Biomarkers</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction</topic><topic>Dementia</topic><topic>Executive function</topic><topic>Humans</topic><topic>Information processing</topic><topic>Investigations</topic><topic>Locus coeruleus</topic><topic>Locus Coeruleus - diagnostic imaging</topic><topic>Locus Coeruleus - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Memory</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Older people</topic><topic>Pathology</topic><topic>Spatial memory</topic><topic>Tau protein</topic><topic>Twins</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, Tyler Reed</creatorcontrib><creatorcontrib>Elman, Jeremy A.</creatorcontrib><creatorcontrib>Beck, Asad</creatorcontrib><creatorcontrib>Fennema-Notestine, Christine</creatorcontrib><creatorcontrib>Gustavson, Daniel E.</creatorcontrib><creatorcontrib>Hagler, Donald J.</creatorcontrib><creatorcontrib>Jack, Amy J.</creatorcontrib><creatorcontrib>Lyons, Michael J.</creatorcontrib><creatorcontrib>Puckett, Olivia K.</creatorcontrib><creatorcontrib>Toomey, Rosemary</creatorcontrib><creatorcontrib>Franz, Carol E.</creatorcontrib><creatorcontrib>Kremen, William S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, Tyler Reed</au><au>Elman, Jeremy A.</au><au>Beck, Asad</au><au>Fennema-Notestine, Christine</au><au>Gustavson, Daniel E.</au><au>Hagler, Donald J.</au><au>Jack, Amy J.</au><au>Lyons, Michael J.</au><au>Puckett, Olivia K.</au><au>Toomey, Rosemary</au><au>Franz, Carol E.</au><au>Kremen, William S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>29</volume><issue>8</issue><spage>763</spage><epage>774</epage><pages>763-774</pages><issn>1355-6177</issn><issn>1469-7661</issn><eissn>1469-7661</eissn><abstract>Abnormal tau, a hallmark Alzheimer's disease (AD) pathology, may appear in the locus coeruleus (LC) decades before AD symptom onset. Reports of subjective cognitive decline are also often present prior to formal diagnosis. Yet, the relationship between LC structural integrity and subjective cognitive decline has remained unexplored. Here, we aimed to explore these potential associations.
We examined 381 community-dwelling men (mean age = 67.58;
= 2.62) in the Vietnam Era Twin Study of Aging who underwent LC-sensitive magnetic resonance imaging and completed the Everyday Cognition scale to measure subjective cognitive decline along with their selected informants. Mixed models examined the associations between rostral-middle and caudal LC integrity and subjective cognitive decline after adjusting for depressive symptoms, physical morbidities, and family. Models also adjusted for current objective cognitive performance and objective cognitive decline to explore attenuation.
For participant ratings, lower rostral-middle LC contrast to noise ratio (LC
) was associated with significantly greater subjective decline in memory, executive function, and visuospatial abilities. For informant ratings, lower rostral-middle LC
was associated with significantly greater subjective decline in memory only. Associations remained after adjusting for current objective cognition and objective cognitive decline in respective domains.
Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>36524301</pmid><doi>10.1017/S1355617722000881</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5702-5995</orcidid><orcidid>https://orcid.org/0000-0002-1470-4928</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6177 |
| ispartof | Journal of the International Neuropsychological Society, 2023-10, Vol.29 (8), p.763-774 |
| issn | 1355-6177 1469-7661 1469-7661 |
| language | eng |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Aged Aging Alzheimer Disease - diagnosis Alzheimer's disease Arousal Biomarkers Cognition Cognitive ability Cognitive Dysfunction Dementia Executive function Humans Information processing Investigations Locus coeruleus Locus Coeruleus - diagnostic imaging Locus Coeruleus - pathology Magnetic resonance imaging Male Medical imaging Memory Neurodegenerative diseases Neuroimaging Older people Pathology Spatial memory Tau protein Twins Visual perception |
| title | Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age |
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