CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis

To investigate the role of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in human osteoarthritis. Paired osteochondral plugs and articular chondrocytes were isolated from the relatively healthier (intact) and damaged portions of human femoral heads collected from patients undergoing...

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Veröffentlicht in:	Osteoarthritis and cartilage 2023-07, Vol.31 (7), p.908-918
Hauptverfasser:	Dilley, J.E., Seetharam, A., Ding, X., Bello, M.A., Shutter, J., Burr, D.B., Natoli, R.M., McKinley, T.O., Sankar, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics CAMKK2 Cartilage, Articular - pathology Catabolism Cells, Cultured Chondrocyte Chondrocytes - metabolism Humans Osteoarthritis Osteoarthritis - metabolism
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