Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with resistance found in a few isolates. Resistance in cli...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2023-06, Vol.67 (6), p.e0017123-e0017123 |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 67 |
| creator | Hall, Carina M Somprasong, Nawarat Hagen, Johannah P Nottingham, Roxanne Sahl, Jason W Webb, Jessica R Mayo, Mark Currie, Bart J Podin, Yuwana Wagner, David M Keim, Paul Schweizer, Herbert P |
| description | Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with
resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia. |
| doi_str_mv | 10.1128/aac.00171-23 |
| format | Article |
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resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.00171-23</identifier><identifier>PMID: 37133377</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antimicrobial Chemotherapy ; Burkholderia pseudomallei ; Cefiderocol ; Cephalosporins - pharmacology ; Cephalosporins - therapeutic use ; Drug Resistance, Multiple, Bacterial - genetics ; Editor's Pick ; Gram-Negative Bacteria ; Mechanisms of Resistance ; Microbial Sensitivity Tests</subject><ispartof>Antimicrobial agents and chemotherapy, 2023-06, Vol.67 (6), p.e0017123-e0017123</ispartof><rights>Copyright © 2023 Hall et al.</rights><rights>Copyright © 2023 Hall et al. 2023 Hall et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a419t-da48fd27e079e9ba54e1de1857e2ca62e4e4aab54be8642b56f8b18fb8ccc4a83</citedby><cites>FETCH-LOGICAL-a419t-da48fd27e079e9ba54e1de1857e2ca62e4e4aab54be8642b56f8b18fb8ccc4a83</cites><orcidid>0000-0003-0089-5820 ; 0000-0002-8847-335X ; 0000-0002-2497-0138</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269091/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269091/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37133377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, Carina M</creatorcontrib><creatorcontrib>Somprasong, Nawarat</creatorcontrib><creatorcontrib>Hagen, Johannah P</creatorcontrib><creatorcontrib>Nottingham, Roxanne</creatorcontrib><creatorcontrib>Sahl, Jason W</creatorcontrib><creatorcontrib>Webb, Jessica R</creatorcontrib><creatorcontrib>Mayo, Mark</creatorcontrib><creatorcontrib>Currie, Bart J</creatorcontrib><creatorcontrib>Podin, Yuwana</creatorcontrib><creatorcontrib>Wagner, David M</creatorcontrib><creatorcontrib>Keim, Paul</creatorcontrib><creatorcontrib>Schweizer, Herbert P</creatorcontrib><title>Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with
resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antimicrobial Chemotherapy</subject><subject>Burkholderia pseudomallei</subject><subject>Cefiderocol</subject><subject>Cephalosporins - pharmacology</subject><subject>Cephalosporins - therapeutic use</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Editor's Pick</subject><subject>Gram-Negative Bacteria</subject><subject>Mechanisms of Resistance</subject><subject>Microbial Sensitivity Tests</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMoun7cPEuPClaTNG2Tk-iirqAIoucwTaduNG3WZCv6763uKnrwNAzz8A7zDCG7jB4xxuUxgDmilJUs5dkKGTGqZFrkqlglI0qLIhWSig2yGeMTHfpc0XWykZUsy7KyHJHJ-dvM-WC7x2SMja0xeONdcofRxjl0BpMbNFPobGxjYrvkrA_PU-8GzkIyi9jXvgXn0G6TtQZcxJ1l3SIPF-f340l6fXt5NT69TkEwNU9rELKpeYm0VKgqyAWyGpnMS-QGCo4CBUCViwplIXiVF42smGwqaYwRILMtcrLInfVVi7XBbh7A6VmwLYR37cHqv5POTvWjf9WM8kJRxYaE_WVC8C89xrlubTToHHTo-6i5pOpTqMoH9HCBmuBjDNj87GFUf9rXg339ZV_zbMAPFjjElusn34duUPEfu_f7jp_g79dkH1wCj60</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>Hall, Carina M</creator><creator>Somprasong, Nawarat</creator><creator>Hagen, Johannah P</creator><creator>Nottingham, Roxanne</creator><creator>Sahl, Jason W</creator><creator>Webb, Jessica R</creator><creator>Mayo, Mark</creator><creator>Currie, Bart J</creator><creator>Podin, Yuwana</creator><creator>Wagner, David M</creator><creator>Keim, Paul</creator><creator>Schweizer, Herbert P</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0089-5820</orcidid><orcidid>https://orcid.org/0000-0002-8847-335X</orcidid><orcidid>https://orcid.org/0000-0002-2497-0138</orcidid></search><sort><creationdate>20230615</creationdate><title>Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei</title><author>Hall, Carina M ; 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resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>37133377</pmid><doi>10.1128/aac.00171-23</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0089-5820</orcidid><orcidid>https://orcid.org/0000-0002-8847-335X</orcidid><orcidid>https://orcid.org/0000-0002-2497-0138</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antimicrobial Chemotherapy Burkholderia pseudomallei Cefiderocol Cephalosporins - pharmacology Cephalosporins - therapeutic use Drug Resistance, Multiple, Bacterial - genetics Editor's Pick Gram-Negative Bacteria Mechanisms of Resistance Microbial Sensitivity Tests |
| title | Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei |
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