Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis

Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highligh...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2023-06, Vol.83 (12), p.1933-1940
Hauptverfasser:	Schepers, Emily J, Glaser, Kathryn, Zwolshen, Harrison M, Hartman, Stephen J, Bondoc, Alexander J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Carcinoma, Hepatocellular - pathology Glypicans - chemistry Glypicans - genetics Glypicans - metabolism Humans Liver Neoplasms - pathology Protein Processing, Post-Translational Review
Online-Zugang:	Volltext
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