Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
Abstract Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Medi...
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| Veröffentlicht in: | The Journal of infectious diseases 2023-06, Vol.227 (12), p.1381-1385 |
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| creator | Poveda, Eva Fitzgerald, Wendy Reglero, Cristina Pérez-González, Alexandre Mariño, Ana Álvarez, Hortensia Valcarce, Nieves Llibre, Josep Maria Guillén, Santiago Moreno Muñoz Fernández, Maria Angeles Ruiz-Mateos, Ezequiel Margolis, Leonid Lederman, Michael M Freeman, Michael L |
| description | Abstract
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
Elite controllers (EC) had higher plasma extracellular vesicle (EV)-associated cytokines than other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 distinguished EC from ART treated; EV-associated IL-3 and TRAIL distinguished PC from TC. |
| doi_str_mv | 10.1093/infdis/jiad042 |
| format | Article |
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Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
Elite controllers (EC) had higher plasma extracellular vesicle (EV)-associated cytokines than other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 distinguished EC from ART treated; EV-associated IL-3 and TRAIL distinguished PC from TC.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiad042</identifier><identifier>PMID: 36790818</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Antiretroviral therapy ; Biomarkers ; Brief Report ; CD4-Positive T-Lymphocytes - metabolism ; Cytokines - metabolism ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; HIV ; HIV Infections ; HIV Seropositivity ; HIV-1 - metabolism ; Human immunodeficiency virus ; Humans ; Interleukin 18 ; Interleukin 3 ; Interleukin-18 - metabolism</subject><ispartof>The Journal of infectious diseases, 2023-06, Vol.227 (12), p.1381-1385</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c408t-5a85416e1808aa3ccdbfe29299a517a6f5b861d5bf714fdcc2bc8f546aa1e8563</cites><orcidid>0000-0003-4835-9875</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36790818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poveda, Eva</creatorcontrib><creatorcontrib>Fitzgerald, Wendy</creatorcontrib><creatorcontrib>Reglero, Cristina</creatorcontrib><creatorcontrib>Pérez-González, Alexandre</creatorcontrib><creatorcontrib>Mariño, Ana</creatorcontrib><creatorcontrib>Álvarez, Hortensia</creatorcontrib><creatorcontrib>Valcarce, Nieves</creatorcontrib><creatorcontrib>Llibre, Josep Maria</creatorcontrib><creatorcontrib>Guillén, Santiago Moreno</creatorcontrib><creatorcontrib>Muñoz Fernández, Maria Angeles</creatorcontrib><creatorcontrib>Ruiz-Mateos, Ezequiel</creatorcontrib><creatorcontrib>Margolis, Leonid</creatorcontrib><creatorcontrib>Lederman, Michael M</creatorcontrib><creatorcontrib>Freeman, Michael L</creatorcontrib><title>Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
Elite controllers (EC) had higher plasma extracellular vesicle (EV)-associated cytokines than other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 distinguished EC from ART treated; EV-associated IL-3 and TRAIL distinguished PC from TC.</description><subject>Antiretroviral therapy</subject><subject>Biomarkers</subject><subject>Brief Report</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - metabolism</subject><subject>HIV</subject><subject>HIV Infections</subject><subject>HIV Seropositivity</subject><subject>HIV-1 - metabolism</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Interleukin 18</subject><subject>Interleukin 3</subject><subject>Interleukin-18 - metabolism</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkcFvFCEYxYmxsWv16tGQeGkP034wAwNejF1Xu8kmXrRXwjBg2bLDFmaa9r-Xza6N9uIFyMfve3kvD6F3BM4JyPrCD673-WLtdQ8NfYFmhNVtxTmpX6IZAKUVEVIeo9c5rwGgqXn7Ch2XU4IgYoZulsNoU7DTrR8wEfh0uSobZ1gPPS7PGpfx4mFM2tgQpqATvrbZm2DzR3zp40anW5sydjHhL1PSXbB4Efxo8TwOY4oBR4evltcVeYOOnA7Zvj3cJ-jn18WP-VW1-v5tOf-8qkwDYqyYFqwh3BIBQuvamL5zlkoqpWak1dyxTnDSs861pHG9MbQzwrGGa02sYLw-QZ_2utup29je2GJDB7VNvnh9VFF79e_P4G_Ur3ivCFDOZUOLwulBIcW7yeZRbXzexdeDjVNWtG1bACnaHfrhGbqOUxpKPlUDI4KBEFCo8z1lUsw5WffkhoDataj2LapDi2Xh_d8ZnvA_tRXgbA_Eafs_sd_gqKdd</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>Poveda, Eva</creator><creator>Fitzgerald, Wendy</creator><creator>Reglero, Cristina</creator><creator>Pérez-González, Alexandre</creator><creator>Mariño, Ana</creator><creator>Álvarez, Hortensia</creator><creator>Valcarce, Nieves</creator><creator>Llibre, Josep Maria</creator><creator>Guillén, Santiago Moreno</creator><creator>Muñoz Fernández, Maria Angeles</creator><creator>Ruiz-Mateos, Ezequiel</creator><creator>Margolis, Leonid</creator><creator>Lederman, Michael M</creator><creator>Freeman, Michael L</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4835-9875</orcidid></search><sort><creationdate>20230615</creationdate><title>Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1</title><author>Poveda, Eva ; Fitzgerald, Wendy ; Reglero, Cristina ; Pérez-González, Alexandre ; Mariño, Ana ; Álvarez, Hortensia ; Valcarce, Nieves ; Llibre, Josep Maria ; Guillén, Santiago Moreno ; Muñoz Fernández, Maria Angeles ; Ruiz-Mateos, Ezequiel ; Margolis, Leonid ; Lederman, Michael M ; Freeman, Michael L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-5a85416e1808aa3ccdbfe29299a517a6f5b861d5bf714fdcc2bc8f546aa1e8563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiretroviral therapy</topic><topic>Biomarkers</topic><topic>Brief Report</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Extracellular vesicles</topic><topic>Extracellular Vesicles - metabolism</topic><topic>HIV</topic><topic>HIV Infections</topic><topic>HIV Seropositivity</topic><topic>HIV-1 - metabolism</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Interleukin 18</topic><topic>Interleukin 3</topic><topic>Interleukin-18 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poveda, Eva</creatorcontrib><creatorcontrib>Fitzgerald, Wendy</creatorcontrib><creatorcontrib>Reglero, Cristina</creatorcontrib><creatorcontrib>Pérez-González, Alexandre</creatorcontrib><creatorcontrib>Mariño, Ana</creatorcontrib><creatorcontrib>Álvarez, Hortensia</creatorcontrib><creatorcontrib>Valcarce, Nieves</creatorcontrib><creatorcontrib>Llibre, Josep Maria</creatorcontrib><creatorcontrib>Guillén, Santiago Moreno</creatorcontrib><creatorcontrib>Muñoz Fernández, Maria Angeles</creatorcontrib><creatorcontrib>Ruiz-Mateos, Ezequiel</creatorcontrib><creatorcontrib>Margolis, Leonid</creatorcontrib><creatorcontrib>Lederman, Michael M</creatorcontrib><creatorcontrib>Freeman, Michael L</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poveda, Eva</au><au>Fitzgerald, Wendy</au><au>Reglero, Cristina</au><au>Pérez-González, Alexandre</au><au>Mariño, Ana</au><au>Álvarez, Hortensia</au><au>Valcarce, Nieves</au><au>Llibre, Josep Maria</au><au>Guillén, Santiago Moreno</au><au>Muñoz Fernández, Maria Angeles</au><au>Ruiz-Mateos, Ezequiel</au><au>Margolis, Leonid</au><au>Lederman, Michael M</au><au>Freeman, Michael L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2023-06-15</date><risdate>2023</risdate><volume>227</volume><issue>12</issue><spage>1381</spage><epage>1385</epage><pages>1381-1385</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
Elite controllers (EC) had higher plasma extracellular vesicle (EV)-associated cytokines than other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 distinguished EC from ART treated; EV-associated IL-3 and TRAIL distinguished PC from TC.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>36790818</pmid><doi>10.1093/infdis/jiad042</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4835-9875</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Antiretroviral therapy Biomarkers Brief Report CD4-Positive T-Lymphocytes - metabolism Cytokines - metabolism Extracellular vesicles Extracellular Vesicles - metabolism HIV HIV Infections HIV Seropositivity HIV-1 - metabolism Human immunodeficiency virus Humans Interleukin 18 Interleukin 3 Interleukin-18 - metabolism |
| title | Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1 |
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