Correlation of inflammatory cytokines and uric acid levels in coronary artery disease with and without type 2 diabetes mellitus
Serum levels of inflammatory cytokines such as IL-6, high-sensitivity C-reactive protein as well as uric acids have been considered as predictors of severe outcomes in patients with coronary artery disease (CAD) associated with hypertension (HTN) and Type 2 Diabetes Mellitus (T2DM). Anthropometric p...
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| Veröffentlicht in: | Bioinformation 2022-08, Vol.18 (8), p.675-682 |
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| creator | Selvakumar, D Vijayasamundeeswari, C K Sendhav, Sandip Ekambaram, Gnanadesigan |
| description | Serum levels of inflammatory cytokines such as IL-6, high-sensitivity C-reactive protein as well as uric acids have been considered as predictors of severe outcomes in patients with coronary artery disease (CAD) associated with hypertension (HTN) and Type 2 Diabetes Mellitus (T2DM). Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. The evaluated high levels of inflammatory cytokines and uric acids in hypertensive CAD patients with diabetes might be helpful in the diagnosis of patients at greater risk. |
| doi_str_mv | 10.6026/97320630018675 |
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Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. The evaluated high levels of inflammatory cytokines and uric acids in hypertensive CAD patients with diabetes might be helpful in the diagnosis of patients at greater risk.</description><identifier>ISSN: 0973-2063</identifier><identifier>ISSN: 0973-8894</identifier><identifier>EISSN: 0973-2063</identifier><identifier>DOI: 10.6026/97320630018675</identifier><identifier>PMID: 37323554</identifier><language>eng</language><publisher>Singapore: Biomedical Informatics</publisher><subject>C-reactive protein ; Cardiovascular disease ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Cytokines ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Heart diseases ; Hypertension ; Inflammation ; Interleukin 6 ; Risk analysis ; Risk factors ; Serum levels ; Statistical analysis ; Uric acid ; Vein & artery diseases</subject><ispartof>Bioinformation, 2022-08, Vol.18 (8), p.675-682</ispartof><rights>2022 Biomedical Informatics.</rights><rights>Copyright Biomedical Informatics Aug 2022</rights><rights>2022 Biomedical Informatics 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37323554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selvakumar, D</creatorcontrib><creatorcontrib>Vijayasamundeeswari, C K</creatorcontrib><creatorcontrib>Sendhav, Sandip</creatorcontrib><creatorcontrib>Ekambaram, Gnanadesigan</creatorcontrib><creatorcontrib>Department of Biochemistry, Vinayaka Mission’s Kirupananda Variyar Medical college and Hospitals , Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem -636 308, Tamilnadu, India</creatorcontrib><title>Correlation of inflammatory cytokines and uric acid levels in coronary artery disease with and without type 2 diabetes mellitus</title><title>Bioinformation</title><addtitle>Bioinformation</addtitle><description>Serum levels of inflammatory cytokines such as IL-6, high-sensitivity C-reactive protein as well as uric acids have been considered as predictors of severe outcomes in patients with coronary artery disease (CAD) associated with hypertension (HTN) and Type 2 Diabetes Mellitus (T2DM). Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. The evaluated high levels of inflammatory cytokines and uric acids in hypertensive CAD patients with diabetes might be helpful in the diagnosis of patients at greater risk.</description><subject>C-reactive protein</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Heart diseases</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Serum levels</subject><subject>Statistical analysis</subject><subject>Uric acid</subject><subject>Vein & artery diseases</subject><issn>0973-2063</issn><issn>0973-8894</issn><issn>0973-2063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkU1PHDEMhqMKVD7aK0cUiUsvC87HJLMnhFYtrYTEhZ6jzMRTAjPJkmRAe-pfb7ZQBD3Zsh-_8msTcsTgVAFXZ0stOCgBwFqlmw9kH2plsS3tvMn3yEHOdwCSad18JHuiTommkfvk9yqmhKMtPgYaB-rDMNppsiWmDe03Jd77gJna4OicfE9t7x0d8RHHXFnaxxSDrahNBWtwPqPNSJ98uf07tE3iXGjZrJHy2rcdlio44Tj6MudPZHewY8bPL_GQ_Pz29Wb1fXF1ffljdXG16AXIslBCAnYcxdBqjqiWrO3ckjspFVjhrGNK87ZBhQPTKAfVQYctsw61AoZSHJLzZ9313E3oegwl2dGsk5_q-iZab953gr81v-KjYfXKSiheFb68KKT4MGMuZvK5rzZswDhnw1uueSOXDCp68h96F-cUqj_DNai2Ad6qSp0-U32KOSccXrdhYLbPNe-fWweO33p4xf99U_wBp76hnQ</recordid><startdate>20220831</startdate><enddate>20220831</enddate><creator>Selvakumar, D</creator><creator>Vijayasamundeeswari, C K</creator><creator>Sendhav, Sandip</creator><creator>Ekambaram, Gnanadesigan</creator><general>Biomedical Informatics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220831</creationdate><title>Correlation of inflammatory cytokines and uric acid levels in coronary artery disease with and without type 2 diabetes mellitus</title><author>Selvakumar, D ; 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Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. 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| subjects | C-reactive protein Cardiovascular disease Coronary artery Coronary artery disease Coronary vessels Cytokines Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Heart diseases Hypertension Inflammation Interleukin 6 Risk analysis Risk factors Serum levels Statistical analysis Uric acid Vein & artery diseases |
| title | Correlation of inflammatory cytokines and uric acid levels in coronary artery disease with and without type 2 diabetes mellitus |
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