Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury

Acute kidney injury (AKI) is a refractory clinical syndrome with limited effective treatments. Amid AKI, activation of the extracellular signal-regulated kinase (ERK) cascade plays a critical role in promoting kidney repair and regeneration. However, a mature ERK agonist in treating kidney disease r...

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Veröffentlicht in:	International journal of biological sciences 2023-01, Vol.19 (9), p.2860-2878
Hauptverfasser:	Zhou, Xianke, Xiang, Yadie, Li, Dier, Zhong, Menghua, Hong, Xue, Gui, Yuan, Min, Wenjian, Chen, Yudan, Zeng, Xi, Zhu, Haili, Liu, Youhua, Liu, Shijia, Yang, Peng, Hou, Fanfan, Zhou, Dong, Fu, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Apoptosis Extracellular Signal-Regulated MAP Kinases Humans Kidney - metabolism Limonins - pharmacology Limonins - therapeutic use Molecular Docking Simulation Research Paper
Online-Zugang:	Volltext
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