Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study
Epigenetic ageing, i.e., age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function and cardiovascular...
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| Veröffentlicht in: | Aging cell 2023-06, Vol.22 (6), p.e13828-n/a |
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| description | Epigenetic ageing, i.e., age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function and cardiovascular risk factors in mediating this relation. Moreover, we aimed to identify novel molecular processes underlying the association between physical activity and epigenetic ageing. We analysed cross‐sectional data from 3567 eligible participants (mean age: 55.5 years, range: 30–94 years, 54.8% women) of the Rhineland Study, a community‐based cohort study in Bonn, Germany. Physical activity components (metabolic equivalent (MET)‐Hours, step counts, sedentary, light‐intensity and moderate‐to‐vigorous intensity activities) were recorded with accelerometers. DNA methylation was measured with the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration (Hannum's age, Horvath's age, PhenoAge and GrimAge) was calculated based on published algorithms. The relation between physical activity and epigenetic ageing was examined with multivariable regression, while structural equation modeling was used for mediation analysis. Moreover, we conducted an epigenome‐wide association study of physical activity across 850,000 CpG sites. After adjustment for age, sex, season, education, smoking, cell proportions and batch effects, physical activity (step counts, MET‐Hours and %time spend in moderate‐to‐vigorous activities) was non‐linearly associated with slower epigenetic ageing, in part through its beneficial effects on immune function and cardiovascular health. Additionally, we identified 12 and 7 CpGs associated with MET‐Hours and %time spent in moderate‐to‐vigorous activities, respectively (p |
| doi_str_mv | 10.1111/acel.13828 |
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In this study, we examined the relation between physical activity and epigenetic ageing in 3567 eligible participants of a large community‐based, prospective cohort study, the Rhineland Study. We show that physical activity is associated with slower epigenetic ageing (GrimAge acceleration and PhenoAge acceleration), which was in part mediated by cardiovascular health and immune function.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/acel.13828</identifier><identifier>PMID: 37036021</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Aging ; Aging - genetics ; biological age ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; cardiovascular risk factors ; Cohort analysis ; Cohort Studies ; CpG islands ; Cross-Sectional Studies ; DNA methylation ; DNA Methylation - genetics ; epidemiology ; Epigenesis, Genetic ; Epigenetics ; Exercise ; Female ; Genes ; Humans ; immune function ; Immune response ; Immunosenescence ; Male ; Middle Aged ; Morbidity ; Mortality ; Neutrophils ; Older people ; Physical activity ; Physical fitness ; public health ; Risk factors</subject><ispartof>Aging cell, 2023-06, Vol.22 (6), p.e13828-n/a</ispartof><rights>2023 The Authors. published by Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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U.</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><creatorcontrib>Aziz, Nasir Ahmad</creatorcontrib><title>Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Epigenetic ageing, i.e., age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function and cardiovascular risk factors in mediating this relation. Moreover, we aimed to identify novel molecular processes underlying the association between physical activity and epigenetic ageing. We analysed cross‐sectional data from 3567 eligible participants (mean age: 55.5 years, range: 30–94 years, 54.8% women) of the Rhineland Study, a community‐based cohort study in Bonn, Germany. Physical activity components (metabolic equivalent (MET)‐Hours, step counts, sedentary, light‐intensity and moderate‐to‐vigorous intensity activities) were recorded with accelerometers. DNA methylation was measured with the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration (Hannum's age, Horvath's age, PhenoAge and GrimAge) was calculated based on published algorithms. The relation between physical activity and epigenetic ageing was examined with multivariable regression, while structural equation modeling was used for mediation analysis. Moreover, we conducted an epigenome‐wide association study of physical activity across 850,000 CpG sites. After adjustment for age, sex, season, education, smoking, cell proportions and batch effects, physical activity (step counts, MET‐Hours and %time spend in moderate‐to‐vigorous activities) was non‐linearly associated with slower epigenetic ageing, in part through its beneficial effects on immune function and cardiovascular health. Additionally, we identified 12 and 7 CpGs associated with MET‐Hours and %time spent in moderate‐to‐vigorous activities, respectively (p < 1 × 10−5). Our findings suggest that regular physical activity slows epigenetic ageing by counteracting immunosenescence and lowering cardiovascular risk.
In this study, we examined the relation between physical activity and epigenetic ageing in 3567 eligible participants of a large community‐based, prospective cohort study, the Rhineland Study. We show that physical activity is associated with slower epigenetic ageing (GrimAge acceleration and PhenoAge acceleration), which was in part mediated by cardiovascular health and immune function.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - genetics</subject><subject>biological age</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>cardiovascular risk factors</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>CpG islands</subject><subject>Cross-Sectional Studies</subject><subject>DNA methylation</subject><subject>DNA Methylation - genetics</subject><subject>epidemiology</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Exercise</subject><subject>Female</subject><subject>Genes</subject><subject>Humans</subject><subject>immune function</subject><subject>Immune response</subject><subject>Immunosenescence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Older people</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>public health</subject><subject>Risk factors</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kdFqFDEUhoMotlZvfAAJeFOErclkZpJcSVnaKiwootchk5zspMxO1iTTZe58CJ_QJzHbrYt6YW5yDvn4OCc_Qi8puaDlvNUGhgvKRCUeoVNa83ohedU-PtZUnKBnKd0SQrkk7Ck6YZywllT0FOlP_Zy80QPWJvs7n2fsE9YpBeN1Bot3Pvc4DWEHEcPWr2GE7A3Wa_Dj-uf3H9d-tKVK2MWwwbkH_Ln3Iwx6tDjlyc7P0ROnhwQvHu4z9PX66svy_WL18ebD8nK1MHUtxYLJVjbG1UBBd5oS0jV1aU3bSScAamI7SYzrOs21bsAAN87ZzlrXGkasY2fo3cG7nboNWANjjnpQ2-g3Os4qaK_-fhl9r9bhTlFStQ0VpBjOHwwxfJsgZbXxqfxt2QXClFTFpaScMSYK-vof9DZMcSz7qUpUDeOCVHvhmwNlYkgpgjtOQ4naR6f20an76Ar86s_5j-jvrApAD8DODzD_R6Uul1erg_QXi0yo2Q</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Fox, Fabienne A. 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B. ; Aziz, Nasir Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4498-39695cf4e1eaba100b54cf4c6b9f8ee40db90cfbba7aa5ece7cffdbddf6c30df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - genetics</topic><topic>biological age</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>cardiovascular risk factors</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>CpG islands</topic><topic>Cross-Sectional Studies</topic><topic>DNA methylation</topic><topic>DNA Methylation - genetics</topic><topic>epidemiology</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Exercise</topic><topic>Female</topic><topic>Genes</topic><topic>Humans</topic><topic>immune function</topic><topic>Immune response</topic><topic>Immunosenescence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>Older people</topic><topic>Physical activity</topic><topic>Physical fitness</topic><topic>public health</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, Fabienne A. U.</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><creatorcontrib>Aziz, Nasir Ahmad</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, Fabienne A. U.</au><au>Liu, Dan</au><au>Breteler, Monique M. B.</au><au>Aziz, Nasir Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2023-06</date><risdate>2023</risdate><volume>22</volume><issue>6</issue><spage>e13828</spage><epage>n/a</epage><pages>e13828-n/a</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Epigenetic ageing, i.e., age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function and cardiovascular risk factors in mediating this relation. Moreover, we aimed to identify novel molecular processes underlying the association between physical activity and epigenetic ageing. We analysed cross‐sectional data from 3567 eligible participants (mean age: 55.5 years, range: 30–94 years, 54.8% women) of the Rhineland Study, a community‐based cohort study in Bonn, Germany. Physical activity components (metabolic equivalent (MET)‐Hours, step counts, sedentary, light‐intensity and moderate‐to‐vigorous intensity activities) were recorded with accelerometers. DNA methylation was measured with the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration (Hannum's age, Horvath's age, PhenoAge and GrimAge) was calculated based on published algorithms. The relation between physical activity and epigenetic ageing was examined with multivariable regression, while structural equation modeling was used for mediation analysis. Moreover, we conducted an epigenome‐wide association study of physical activity across 850,000 CpG sites. After adjustment for age, sex, season, education, smoking, cell proportions and batch effects, physical activity (step counts, MET‐Hours and %time spend in moderate‐to‐vigorous activities) was non‐linearly associated with slower epigenetic ageing, in part through its beneficial effects on immune function and cardiovascular health. Additionally, we identified 12 and 7 CpGs associated with MET‐Hours and %time spent in moderate‐to‐vigorous activities, respectively (p < 1 × 10−5). Our findings suggest that regular physical activity slows epigenetic ageing by counteracting immunosenescence and lowering cardiovascular risk.
In this study, we examined the relation between physical activity and epigenetic ageing in 3567 eligible participants of a large community‐based, prospective cohort study, the Rhineland Study. We show that physical activity is associated with slower epigenetic ageing (GrimAge acceleration and PhenoAge acceleration), which was in part mediated by cardiovascular health and immune function.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>37036021</pmid><doi>10.1111/acel.13828</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-6732-7433</orcidid><orcidid>https://orcid.org/0000-0002-0656-219X</orcidid><orcidid>https://orcid.org/0000-0001-6184-458X</orcidid><orcidid>https://orcid.org/0000-0002-0626-9305</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Aging Aging - genetics biological age Blood pressure Cardiovascular disease Cardiovascular diseases cardiovascular risk factors Cohort analysis Cohort Studies CpG islands Cross-Sectional Studies DNA methylation DNA Methylation - genetics epidemiology Epigenesis, Genetic Epigenetics Exercise Female Genes Humans immune function Immune response Immunosenescence Male Middle Aged Morbidity Mortality Neutrophils Older people Physical activity Physical fitness public health Risk factors |
| title | Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study |
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