Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson‐Gilford progeria syndrome in mice

Partial cellular reprogramming via transient expression of Oct4, Sox2, Klf4, and c‐Myc induces rejuvenation and reduces aged‐cell phenotypes. In this study, we found that transcriptional activation of the endogenous Oct4 gene by using the CRISPR/dCas9 activator system can efficiently ameliorate hall...

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Veröffentlicht in:	Aging cell 2023-06, Vol.22 (6), p.e13825-n/a
Hauptverfasser:	Kim, Junyeop, Hwang, Yerim, Kim, Sumin, Chang, Yujung, Kim, Yunkyung, Kwon, Youngeun, Kim, Jongpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animals Aorta c-Myc protein Cellular Reprogramming Clustered Regularly Interspaced Short Palindromic Repeats CRISPR CRISPR/dCas9 Disease Models, Animal Epigenetics Fibroblasts Gene expression Hutchinson‐Gilford progeria syndrome KLF4 protein Lamin Type A - genetics Lamin Type A - metabolism Life span Mice Mutation Myc protein Oct-4 protein Oct4 Phenotypes Progeria Progeria - metabolism rejuvenation Stem cells Transcription activation Transcriptional Activation - genetics
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