How Azide Ion/Hydrazoic Acid Passes Through Biological Membranes: An Experimental and Computational Study

Hydrazoic acid (HN 3 ) and its deprotonated form azide ion (N 3 − ) (AHA) are toxic because they inhibit the cytochrome c oxidase complex IV (CoX IV) embedded in the inner mitochondrial membrane that forms part of the enzyme complexes involved in cellular respiration. Critical to its toxicity is the...

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Veröffentlicht in:	The Protein Journal 2023-06, Vol.42 (3), p.229-238
Hauptverfasser:	Hartl, Simona Lojevec, Žakelj, Simon, Dolenc, Marija Sollner, Smrkolj, Vladimir, Mavri, Janez
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Angiotensin II receptor blockers Animal Anatomy Aqueous solutions Biochemistry Biological membranes Bioorganic Chemistry Bupivacaine Cardiovascular system Cell membranes Central nervous system Chemistry Chemistry and Materials Science Cytochrome oxidase Cytochrome-c oxidase Cytochromes Diffusion rate Histology Hydrazoic acid Membrane permeability Membranes Mitochondria Morphology Octanol Octanol-water partition coefficients Organic Chemistry Permeability pH effects Toxicity
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