Toxicity of C9orf72 -associated dipeptide repeat peptides is modified by commonly used protein tags

Hexanucleotide repeat expansions in the gene are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Transcripts of the expansions are translated into toxic dipeptide repeat (DPR) proteins. Most preclinical studies in cell and animal models have used protei...

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Veröffentlicht in:	Life science alliance 2023-09, Vol.6 (9), p.e202201739
Hauptverfasser:	Morón-Oset, Javier, Fischer, Lilly Ks, Carcolé, Mireia, Giblin, Ashling, Zhang, Pingze, Isaacs, Adrian M, Grönke, Sebastian, Partridge, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis Animals C9orf72 Protein Dipeptides Drosophila Genes, Regulator Peptides Skin Neoplasms
Online-Zugang:	Volltext
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