Antioxidant, anti‐inflammatory, and anticancer function of Engleromyces goetzei Henn aqueous extract on human intestinal Caco‐2 cells treated with t‐BHP
High body mass index (high BMI, obesity) is a serious public health problem, and “obesity‐induced oxidative stress, inflammation, and cancer” have become modern epidemic diseases. We carried out this study to explore a functional beverage that may protect against obesity‐induced diseases. The Engler...
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| Veröffentlicht in: | Food Science & Nutrition 2023-06, Vol.11 (6), p.3450-3463 |
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| creator | Jun, Ni Yi‐Ting, Cheng Yu‐Ting, Gao Cheng‐Fa, Zhao Li‐Juan, Li Rong, She Xiao‐yan, Yang Wen, Xiao Xu, Yang |
| description | High body mass index (high BMI, obesity) is a serious public health problem, and “obesity‐induced oxidative stress, inflammation, and cancer” have become modern epidemic diseases. We carried out this study to explore a functional beverage that may protect against obesity‐induced diseases. The Engleromyces goetzei Henn herbal tea is such a candidate. For this study, we carried out LC–MS analysis of E. goetzei Henn aqueous extract (EgH‐AE); then used the Caco‐2 cell line for the model cells and treated the cells with t‐BHP to form an oxidative stress system. An MTT assay was used for testing the biocompatibility and cytoprotective effects; reactive oxygen species and malondialdehyde determination was used for evaluating the antioxidative stress effect; TNF‐α and IL‐1β were used for observing the anti‐inflammatory effect, and 8‐OHdG for monitoring anticancer activity. The results of this study demonstrate that the EgH‐AE has very good biocompatibility with the Caco‐2 cell line and has good cytoprotective, antioxidant, anti‐inflammatory, and anticancer properties. It is clear that EgH‐AE, a kind of ancient herbal tea, may be used to develop a functional beverage that can be given to people with a high BMI to protect against obesity‐induced diseases.
Engleromyces goetzei Henn (EgH) is a natural fungus that has been used as a traditional edible and medicine for long time in Southwest China. Our study found EgH aqueous extract (EgH‐AE) has very strong activities on antioxidant and anti‐inflammation. At the same time, we also found EgH‐AE has good biocompatibility and cell protective function, so it is biosafe, EgH‐AE may have the prospect of developing into functional beverage. |
| doi_str_mv | 10.1002/fsn3.3335 |
| format | Article |
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Engleromyces goetzei Henn (EgH) is a natural fungus that has been used as a traditional edible and medicine for long time in Southwest China. Our study found EgH aqueous extract (EgH‐AE) has very strong activities on antioxidant and anti‐inflammation. At the same time, we also found EgH‐AE has good biocompatibility and cell protective function, so it is biosafe, EgH‐AE may have the prospect of developing into functional beverage.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.3335</identifier><identifier>PMID: 37324905</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Acids ; Analysis ; anticancer ; Anticancer properties ; Antioxidants ; antioxidative stress ; Antitumor activity ; anti‐inflammatory ; Beverages ; Biocompatibility ; Bioengineering ; Biotechnology ; Blueberries ; Body mass index ; Body size ; Cancer ; Care and treatment ; Engleromyces goetzei Henn (EgH) ; Ethanol ; Food ; Functional foods & nutraceuticals ; Fungi ; Herbal tea ; Inflammation ; LC–MS analysis ; Medical research ; Medicine, Experimental ; Obesity ; obesity‐induced diseases ; Original ; Oxidative stress ; Public health ; Reactive oxygen species ; Reagents ; Solvents ; Tea ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Food Science & Nutrition, 2023-06, Vol.11 (6), p.3450-3463</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>COPYRIGHT 2023 John Wiley & Sons, Inc.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5115-bea3a70fe5c30a0de874869cc5c595a11e049b4e47d5b061d8d27a8dc0f0ebfe3</citedby><cites>FETCH-LOGICAL-c5115-bea3a70fe5c30a0de874869cc5c595a11e049b4e47d5b061d8d27a8dc0f0ebfe3</cites><orcidid>0000-0002-0475-2619</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261740/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261740/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11542,27903,27904,45553,45554,46031,46455,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37324905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jun, Ni</creatorcontrib><creatorcontrib>Yi‐Ting, Cheng</creatorcontrib><creatorcontrib>Yu‐Ting, Gao</creatorcontrib><creatorcontrib>Cheng‐Fa, Zhao</creatorcontrib><creatorcontrib>Li‐Juan, Li</creatorcontrib><creatorcontrib>Rong, She</creatorcontrib><creatorcontrib>Xiao‐yan, Yang</creatorcontrib><creatorcontrib>Wen, Xiao</creatorcontrib><creatorcontrib>Xu, Yang</creatorcontrib><title>Antioxidant, anti‐inflammatory, and anticancer function of Engleromyces goetzei Henn aqueous extract on human intestinal Caco‐2 cells treated with t‐BHP</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>High body mass index (high BMI, obesity) is a serious public health problem, and “obesity‐induced oxidative stress, inflammation, and cancer” have become modern epidemic diseases. We carried out this study to explore a functional beverage that may protect against obesity‐induced diseases. The Engleromyces goetzei Henn herbal tea is such a candidate. For this study, we carried out LC–MS analysis of E. goetzei Henn aqueous extract (EgH‐AE); then used the Caco‐2 cell line for the model cells and treated the cells with t‐BHP to form an oxidative stress system. An MTT assay was used for testing the biocompatibility and cytoprotective effects; reactive oxygen species and malondialdehyde determination was used for evaluating the antioxidative stress effect; TNF‐α and IL‐1β were used for observing the anti‐inflammatory effect, and 8‐OHdG for monitoring anticancer activity. The results of this study demonstrate that the EgH‐AE has very good biocompatibility with the Caco‐2 cell line and has good cytoprotective, antioxidant, anti‐inflammatory, and anticancer properties. It is clear that EgH‐AE, a kind of ancient herbal tea, may be used to develop a functional beverage that can be given to people with a high BMI to protect against obesity‐induced diseases.
Engleromyces goetzei Henn (EgH) is a natural fungus that has been used as a traditional edible and medicine for long time in Southwest China. Our study found EgH aqueous extract (EgH‐AE) has very strong activities on antioxidant and anti‐inflammation. At the same time, we also found EgH‐AE has good biocompatibility and cell protective function, so it is biosafe, EgH‐AE may have the prospect of developing into functional beverage.</description><subject>Acids</subject><subject>Analysis</subject><subject>anticancer</subject><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>antioxidative stress</subject><subject>Antitumor activity</subject><subject>anti‐inflammatory</subject><subject>Beverages</subject><subject>Biocompatibility</subject><subject>Bioengineering</subject><subject>Biotechnology</subject><subject>Blueberries</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Engleromyces goetzei Henn (EgH)</subject><subject>Ethanol</subject><subject>Food</subject><subject>Functional foods & nutraceuticals</subject><subject>Fungi</subject><subject>Herbal tea</subject><subject>Inflammation</subject><subject>LC–MS analysis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Obesity</subject><subject>obesity‐induced diseases</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Public health</subject><subject>Reactive oxygen species</subject><subject>Reagents</subject><subject>Solvents</subject><subject>Tea</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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anti‐inflammatory, and anticancer function of Engleromyces goetzei Henn aqueous extract on human intestinal Caco‐2 cells treated with t‐BHP</title><author>Jun, Ni ; Yi‐Ting, Cheng ; Yu‐Ting, Gao ; Cheng‐Fa, Zhao ; Li‐Juan, Li ; Rong, She ; Xiao‐yan, Yang ; Wen, Xiao ; Xu, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5115-bea3a70fe5c30a0de874869cc5c595a11e049b4e47d5b061d8d27a8dc0f0ebfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>anticancer</topic><topic>Anticancer properties</topic><topic>Antioxidants</topic><topic>antioxidative stress</topic><topic>Antitumor activity</topic><topic>anti‐inflammatory</topic><topic>Beverages</topic><topic>Biocompatibility</topic><topic>Bioengineering</topic><topic>Biotechnology</topic><topic>Blueberries</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Engleromyces goetzei Henn (EgH)</topic><topic>Ethanol</topic><topic>Food</topic><topic>Functional foods & nutraceuticals</topic><topic>Fungi</topic><topic>Herbal tea</topic><topic>Inflammation</topic><topic>LC–MS analysis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Obesity</topic><topic>obesity‐induced diseases</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Public health</topic><topic>Reactive oxygen species</topic><topic>Reagents</topic><topic>Solvents</topic><topic>Tea</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jun, Ni</creatorcontrib><creatorcontrib>Yi‐Ting, Cheng</creatorcontrib><creatorcontrib>Yu‐Ting, Gao</creatorcontrib><creatorcontrib>Cheng‐Fa, Zhao</creatorcontrib><creatorcontrib>Li‐Juan, 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Li</au><au>Rong, She</au><au>Xiao‐yan, Yang</au><au>Wen, Xiao</au><au>Xu, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant, anti‐inflammatory, and anticancer function of Engleromyces goetzei Henn aqueous extract on human intestinal Caco‐2 cells treated with t‐BHP</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2023-06</date><risdate>2023</risdate><volume>11</volume><issue>6</issue><spage>3450</spage><epage>3463</epage><pages>3450-3463</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>High body mass index (high BMI, obesity) is a serious public health problem, and “obesity‐induced oxidative stress, inflammation, and cancer” have become modern epidemic diseases. We carried out this study to explore a functional beverage that may protect against obesity‐induced diseases. The Engleromyces goetzei Henn herbal tea is such a candidate. For this study, we carried out LC–MS analysis of E. goetzei Henn aqueous extract (EgH‐AE); then used the Caco‐2 cell line for the model cells and treated the cells with t‐BHP to form an oxidative stress system. An MTT assay was used for testing the biocompatibility and cytoprotective effects; reactive oxygen species and malondialdehyde determination was used for evaluating the antioxidative stress effect; TNF‐α and IL‐1β were used for observing the anti‐inflammatory effect, and 8‐OHdG for monitoring anticancer activity. The results of this study demonstrate that the EgH‐AE has very good biocompatibility with the Caco‐2 cell line and has good cytoprotective, antioxidant, anti‐inflammatory, and anticancer properties. It is clear that EgH‐AE, a kind of ancient herbal tea, may be used to develop a functional beverage that can be given to people with a high BMI to protect against obesity‐induced diseases.
Engleromyces goetzei Henn (EgH) is a natural fungus that has been used as a traditional edible and medicine for long time in Southwest China. Our study found EgH aqueous extract (EgH‐AE) has very strong activities on antioxidant and anti‐inflammation. At the same time, we also found EgH‐AE has good biocompatibility and cell protective function, so it is biosafe, EgH‐AE may have the prospect of developing into functional beverage.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>37324905</pmid><doi>10.1002/fsn3.3335</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-0475-2619</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Science & Nutrition, 2023-06, Vol.11 (6), p.3450-3463 |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acids Analysis anticancer Anticancer properties Antioxidants antioxidative stress Antitumor activity anti‐inflammatory Beverages Biocompatibility Bioengineering Biotechnology Blueberries Body mass index Body size Cancer Care and treatment Engleromyces goetzei Henn (EgH) Ethanol Food Functional foods & nutraceuticals Fungi Herbal tea Inflammation LC–MS analysis Medical research Medicine, Experimental Obesity obesity‐induced diseases Original Oxidative stress Public health Reactive oxygen species Reagents Solvents Tea Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Antioxidant, anti‐inflammatory, and anticancer function of Engleromyces goetzei Henn aqueous extract on human intestinal Caco‐2 cells treated with t‐BHP |
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