Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)
Background Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span. Objective To examine the relationship between urine profiles of essential and non-essential metals in mother-offspr...
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| Veröffentlicht in: | Journal of exposure science & environmental epidemiology 2023-11, Vol.33 (6), p.855-864 |
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| creator | El Muayed, Malek Wang, Janice C. Wong, Winifred P. Metzger, Boyd E. Zumpf, Katelyn B. Gurra, Miranda G. Sponenburg, Rebecca A. Hayes, M. Geoffrey Scholtens, Denise M. Lowe, Lynn P. Lowe, William L. |
| description | Background
Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span.
Objective
To examine the relationship between urine profiles of essential and non-essential metals in mother-offspring pairs and their association with early dysglycemia.
Methods
Herein, we report findings from an ancillary study to the international Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO-FUS) that examined urinary essential and non-essential metal profiles from mothers and offspring ages 10–14 years (1012 mothers, 1013 offspring, 968 matched pairs) from 10 international sites.
Results
Our analysis demonstrated a diverse exposure pattern across participating sites. In multiple regression modelling, a positive association between markers of early dysglycemia and urinary zinc was found in both mothers and offspring after adjustment for common risk factors for diabetes. The analysis showed weaker, positive, and negative associations of the 2-h glucose value with urinary selenium and arsenic respectively. A positive association between 2-h glucose values and cadmium was found only in mothers in the fully adjusted model when participants with established diabetes were excluded. There was a high degree of concordance between mother and offspring urinary metal profiles. Mother-to-offspring urinary metal ratios were unique for each metal, providing insights into changes in their homeostasis across the lifespan.
Significance
Urinary levels of essential and non-essential metals are closely correlated between mothers and their offspring in an international cohort. Urinary levels of zinc, selenium, arsenic, and cadmium showed varying degrees of association with early dysglycemia in a comparatively healthy cohort with a low rate of preexisting diabetes.
Impact statement
Our data provides novel evidence for a strong correlation between mother and offspring urinary metal patterns with a unique mother-to-offspring ratio for each metal. The study also provides new evidence for a strong positive association between early dysglycemia and urinary zinc, both in mothers and offspring. Weaker positive associations with urinary selenium and cadmium and negative associations with arsenic were also found. The low rate of preexisting diabetes in this population provides the unique advantage of minimizing the confounding effect of preexisting, diabetes related renal changes t |
| doi_str_mv | 10.1038/s41370-022-00511-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10261541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2904031581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-b4a72ab83c9671cbf219556d0a3666815c87fa74fe0141c3078f4e8ae7c28b843</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhy0Eou3CC3BAlri0h4D_JXFOaFWxbKVKW6msxM1yHGfXVWIH22mVvhlvh7cpC1w42dJ885vRfAC8w-gjRpR_CgzTEmWIkAyhHOPs8QU4xXleZahg318e_xSfgLMQ7hBirCzQa3BCixxVnJJT8HPrjZV-gr2OsoODd63pdIDGwt7FvfaZa9swJGgHB2l8gNI2MBWMhzIEp4yMxln4YOIeaum7CTZT2HWT0r2Rh5jEwisbtbdPZBqyngbtj8ghb9ncax80vPF6Z6VVE9yMUblew5XrOvcAtwO8jWMzwfP18maTrba3F2_Aq1Z2Qb99fhdgu_ry7XKdXW--Xl0urzNFOYlZzWRJZM2pqooSq7oluMrzokGSFkXBca542cqStRphhhVFJW-Z5lKXivCaM7oAn-fcYax73Shto5edSCfp092Ek0b8W7FmL3buXmBECpwnRwvw4TnBux-jDlHcuTGdowuCVIghinN-oMhMKe9C8Lo9jsBIHHyL2bdIvsWTb_GYmt7_vdyx5bfgBNAZmB1q_2f2f2J_AQgEuxo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2904031581</pqid></control><display><type>article</type><title>Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>El Muayed, Malek ; Wang, Janice C. ; Wong, Winifred P. ; Metzger, Boyd E. ; Zumpf, Katelyn B. ; Gurra, Miranda G. ; Sponenburg, Rebecca A. ; Hayes, M. Geoffrey ; Scholtens, Denise M. ; Lowe, Lynn P. ; Lowe, William L.</creator><creatorcontrib>El Muayed, Malek ; Wang, Janice C. ; Wong, Winifred P. ; Metzger, Boyd E. ; Zumpf, Katelyn B. ; Gurra, Miranda G. ; Sponenburg, Rebecca A. ; Hayes, M. Geoffrey ; Scholtens, Denise M. ; Lowe, Lynn P. ; Lowe, William L.</creatorcontrib><description>Background
Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span.
Objective
To examine the relationship between urine profiles of essential and non-essential metals in mother-offspring pairs and their association with early dysglycemia.
Methods
Herein, we report findings from an ancillary study to the international Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO-FUS) that examined urinary essential and non-essential metal profiles from mothers and offspring ages 10–14 years (1012 mothers, 1013 offspring, 968 matched pairs) from 10 international sites.
Results
Our analysis demonstrated a diverse exposure pattern across participating sites. In multiple regression modelling, a positive association between markers of early dysglycemia and urinary zinc was found in both mothers and offspring after adjustment for common risk factors for diabetes. The analysis showed weaker, positive, and negative associations of the 2-h glucose value with urinary selenium and arsenic respectively. A positive association between 2-h glucose values and cadmium was found only in mothers in the fully adjusted model when participants with established diabetes were excluded. There was a high degree of concordance between mother and offspring urinary metal profiles. Mother-to-offspring urinary metal ratios were unique for each metal, providing insights into changes in their homeostasis across the lifespan.
Significance
Urinary levels of essential and non-essential metals are closely correlated between mothers and their offspring in an international cohort. Urinary levels of zinc, selenium, arsenic, and cadmium showed varying degrees of association with early dysglycemia in a comparatively healthy cohort with a low rate of preexisting diabetes.
Impact statement
Our data provides novel evidence for a strong correlation between mother and offspring urinary metal patterns with a unique mother-to-offspring ratio for each metal. The study also provides new evidence for a strong positive association between early dysglycemia and urinary zinc, both in mothers and offspring. Weaker positive associations with urinary selenium and cadmium and negative associations with arsenic were also found. The low rate of preexisting diabetes in this population provides the unique advantage of minimizing the confounding effect of preexisting, diabetes related renal changes that would alter the relationship between dysglycemia and renal metal excretion.</description><identifier>ISSN: 1559-0631</identifier><identifier>EISSN: 1559-064X</identifier><identifier>DOI: 10.1038/s41370-022-00511-z</identifier><identifier>PMID: 36509832</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Arsenic ; Blood Glucose - analysis ; Cadmium ; Clinical outcomes ; Diabetes ; Diabetes Mellitus ; Diet ; Dietary guidelines ; Dietary intake ; Epidemiology ; Female ; Follow-Up Studies ; Food intake ; Glucose ; Heavy metals ; Homeostasis ; Humans ; Hyperglycemia ; Hyperglycemia - epidemiology ; Life span ; Medicine ; Medicine & Public Health ; Metals ; Metals - urine ; Mothers ; Offspring ; Pregnancy ; Pregnancy Outcome ; Regression analysis ; Renal function ; Risk factors ; RNA-Binding Protein FUS ; Selenium ; Trace metals ; Zinc</subject><ispartof>Journal of exposure science & environmental epidemiology, 2023-11, Vol.33 (6), p.855-864</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c382t-b4a72ab83c9671cbf219556d0a3666815c87fa74fe0141c3078f4e8ae7c28b843</cites><orcidid>0000-0001-8669-9681 ; 0000-0002-1879-6575 ; 0000-0001-7771-2004 ; 0000-0002-8252-7863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41370-022-00511-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41370-022-00511-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36509832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Muayed, Malek</creatorcontrib><creatorcontrib>Wang, Janice C.</creatorcontrib><creatorcontrib>Wong, Winifred P.</creatorcontrib><creatorcontrib>Metzger, Boyd E.</creatorcontrib><creatorcontrib>Zumpf, Katelyn B.</creatorcontrib><creatorcontrib>Gurra, Miranda G.</creatorcontrib><creatorcontrib>Sponenburg, Rebecca A.</creatorcontrib><creatorcontrib>Hayes, M. Geoffrey</creatorcontrib><creatorcontrib>Scholtens, Denise M.</creatorcontrib><creatorcontrib>Lowe, Lynn P.</creatorcontrib><creatorcontrib>Lowe, William L.</creatorcontrib><title>Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)</title><title>Journal of exposure science & environmental epidemiology</title><addtitle>J Expo Sci Environ Epidemiol</addtitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><description>Background
Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span.
Objective
To examine the relationship between urine profiles of essential and non-essential metals in mother-offspring pairs and their association with early dysglycemia.
Methods
Herein, we report findings from an ancillary study to the international Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO-FUS) that examined urinary essential and non-essential metal profiles from mothers and offspring ages 10–14 years (1012 mothers, 1013 offspring, 968 matched pairs) from 10 international sites.
Results
Our analysis demonstrated a diverse exposure pattern across participating sites. In multiple regression modelling, a positive association between markers of early dysglycemia and urinary zinc was found in both mothers and offspring after adjustment for common risk factors for diabetes. The analysis showed weaker, positive, and negative associations of the 2-h glucose value with urinary selenium and arsenic respectively. A positive association between 2-h glucose values and cadmium was found only in mothers in the fully adjusted model when participants with established diabetes were excluded. There was a high degree of concordance between mother and offspring urinary metal profiles. Mother-to-offspring urinary metal ratios were unique for each metal, providing insights into changes in their homeostasis across the lifespan.
Significance
Urinary levels of essential and non-essential metals are closely correlated between mothers and their offspring in an international cohort. Urinary levels of zinc, selenium, arsenic, and cadmium showed varying degrees of association with early dysglycemia in a comparatively healthy cohort with a low rate of preexisting diabetes.
Impact statement
Our data provides novel evidence for a strong correlation between mother and offspring urinary metal patterns with a unique mother-to-offspring ratio for each metal. The study also provides new evidence for a strong positive association between early dysglycemia and urinary zinc, both in mothers and offspring. Weaker positive associations with urinary selenium and cadmium and negative associations with arsenic were also found. The low rate of preexisting diabetes in this population provides the unique advantage of minimizing the confounding effect of preexisting, diabetes related renal changes that would alter the relationship between dysglycemia and renal metal excretion.</description><subject>Arsenic</subject><subject>Blood Glucose - analysis</subject><subject>Cadmium</subject><subject>Clinical outcomes</subject><subject>Diabetes</subject><subject>Diabetes Mellitus</subject><subject>Diet</subject><subject>Dietary guidelines</subject><subject>Dietary intake</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Food intake</subject><subject>Glucose</subject><subject>Heavy metals</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - epidemiology</subject><subject>Life span</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metals</subject><subject>Metals - urine</subject><subject>Mothers</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Risk factors</subject><subject>RNA-Binding Protein FUS</subject><subject>Selenium</subject><subject>Trace metals</subject><subject>Zinc</subject><issn>1559-0631</issn><issn>1559-064X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc9u1DAQhy0Eou3CC3BAlri0h4D_JXFOaFWxbKVKW6msxM1yHGfXVWIH22mVvhlvh7cpC1w42dJ885vRfAC8w-gjRpR_CgzTEmWIkAyhHOPs8QU4xXleZahg318e_xSfgLMQ7hBirCzQa3BCixxVnJJT8HPrjZV-gr2OsoODd63pdIDGwt7FvfaZa9swJGgHB2l8gNI2MBWMhzIEp4yMxln4YOIeaum7CTZT2HWT0r2Rh5jEwisbtbdPZBqyngbtj8ghb9ncax80vPF6Z6VVE9yMUblew5XrOvcAtwO8jWMzwfP18maTrba3F2_Aq1Z2Qb99fhdgu_ry7XKdXW--Xl0urzNFOYlZzWRJZM2pqooSq7oluMrzokGSFkXBca542cqStRphhhVFJW-Z5lKXivCaM7oAn-fcYax73Shto5edSCfp092Ek0b8W7FmL3buXmBECpwnRwvw4TnBux-jDlHcuTGdowuCVIghinN-oMhMKe9C8Lo9jsBIHHyL2bdIvsWTb_GYmt7_vdyx5bfgBNAZmB1q_2f2f2J_AQgEuxo</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>El Muayed, Malek</creator><creator>Wang, Janice C.</creator><creator>Wong, Winifred P.</creator><creator>Metzger, Boyd E.</creator><creator>Zumpf, Katelyn B.</creator><creator>Gurra, Miranda G.</creator><creator>Sponenburg, Rebecca A.</creator><creator>Hayes, M. Geoffrey</creator><creator>Scholtens, Denise M.</creator><creator>Lowe, Lynn P.</creator><creator>Lowe, William L.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7ST</scope><scope>7T2</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8669-9681</orcidid><orcidid>https://orcid.org/0000-0002-1879-6575</orcidid><orcidid>https://orcid.org/0000-0001-7771-2004</orcidid><orcidid>https://orcid.org/0000-0002-8252-7863</orcidid></search><sort><creationdate>20231101</creationdate><title>Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)</title><author>El Muayed, Malek ; Wang, Janice C. ; Wong, Winifred P. ; Metzger, Boyd E. ; Zumpf, Katelyn B. ; Gurra, Miranda G. ; Sponenburg, Rebecca A. ; Hayes, M. Geoffrey ; Scholtens, Denise M. ; Lowe, Lynn P. ; Lowe, William L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-b4a72ab83c9671cbf219556d0a3666815c87fa74fe0141c3078f4e8ae7c28b843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Arsenic</topic><topic>Blood Glucose - analysis</topic><topic>Cadmium</topic><topic>Clinical outcomes</topic><topic>Diabetes</topic><topic>Diabetes Mellitus</topic><topic>Diet</topic><topic>Dietary guidelines</topic><topic>Dietary intake</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Food intake</topic><topic>Glucose</topic><topic>Heavy metals</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - epidemiology</topic><topic>Life span</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metals</topic><topic>Metals - urine</topic><topic>Mothers</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Risk factors</topic><topic>RNA-Binding Protein FUS</topic><topic>Selenium</topic><topic>Trace metals</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Muayed, Malek</creatorcontrib><creatorcontrib>Wang, Janice C.</creatorcontrib><creatorcontrib>Wong, Winifred P.</creatorcontrib><creatorcontrib>Metzger, Boyd E.</creatorcontrib><creatorcontrib>Zumpf, Katelyn B.</creatorcontrib><creatorcontrib>Gurra, Miranda G.</creatorcontrib><creatorcontrib>Sponenburg, Rebecca A.</creatorcontrib><creatorcontrib>Hayes, M. Geoffrey</creatorcontrib><creatorcontrib>Scholtens, Denise M.</creatorcontrib><creatorcontrib>Lowe, Lynn P.</creatorcontrib><creatorcontrib>Lowe, William L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of exposure science & environmental epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Muayed, Malek</au><au>Wang, Janice C.</au><au>Wong, Winifred P.</au><au>Metzger, Boyd E.</au><au>Zumpf, Katelyn B.</au><au>Gurra, Miranda G.</au><au>Sponenburg, Rebecca A.</au><au>Hayes, M. Geoffrey</au><au>Scholtens, Denise M.</au><au>Lowe, Lynn P.</au><au>Lowe, William L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)</atitle><jtitle>Journal of exposure science & environmental epidemiology</jtitle><stitle>J Expo Sci Environ Epidemiol</stitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>33</volume><issue>6</issue><spage>855</spage><epage>864</epage><pages>855-864</pages><issn>1559-0631</issn><eissn>1559-064X</eissn><abstract>Background
Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span.
Objective
To examine the relationship between urine profiles of essential and non-essential metals in mother-offspring pairs and their association with early dysglycemia.
Methods
Herein, we report findings from an ancillary study to the international Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO-FUS) that examined urinary essential and non-essential metal profiles from mothers and offspring ages 10–14 years (1012 mothers, 1013 offspring, 968 matched pairs) from 10 international sites.
Results
Our analysis demonstrated a diverse exposure pattern across participating sites. In multiple regression modelling, a positive association between markers of early dysglycemia and urinary zinc was found in both mothers and offspring after adjustment for common risk factors for diabetes. The analysis showed weaker, positive, and negative associations of the 2-h glucose value with urinary selenium and arsenic respectively. A positive association between 2-h glucose values and cadmium was found only in mothers in the fully adjusted model when participants with established diabetes were excluded. There was a high degree of concordance between mother and offspring urinary metal profiles. Mother-to-offspring urinary metal ratios were unique for each metal, providing insights into changes in their homeostasis across the lifespan.
Significance
Urinary levels of essential and non-essential metals are closely correlated between mothers and their offspring in an international cohort. Urinary levels of zinc, selenium, arsenic, and cadmium showed varying degrees of association with early dysglycemia in a comparatively healthy cohort with a low rate of preexisting diabetes.
Impact statement
Our data provides novel evidence for a strong correlation between mother and offspring urinary metal patterns with a unique mother-to-offspring ratio for each metal. The study also provides new evidence for a strong positive association between early dysglycemia and urinary zinc, both in mothers and offspring. Weaker positive associations with urinary selenium and cadmium and negative associations with arsenic were also found. The low rate of preexisting diabetes in this population provides the unique advantage of minimizing the confounding effect of preexisting, diabetes related renal changes that would alter the relationship between dysglycemia and renal metal excretion.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>36509832</pmid><doi>10.1038/s41370-022-00511-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8669-9681</orcidid><orcidid>https://orcid.org/0000-0002-1879-6575</orcidid><orcidid>https://orcid.org/0000-0001-7771-2004</orcidid><orcidid>https://orcid.org/0000-0002-8252-7863</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1559-0631 |
| ispartof | Journal of exposure science & environmental epidemiology, 2023-11, Vol.33 (6), p.855-864 |
| issn | 1559-0631 1559-064X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10261541 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Arsenic Blood Glucose - analysis Cadmium Clinical outcomes Diabetes Diabetes Mellitus Diet Dietary guidelines Dietary intake Epidemiology Female Follow-Up Studies Food intake Glucose Heavy metals Homeostasis Humans Hyperglycemia Hyperglycemia - epidemiology Life span Medicine Medicine & Public Health Metals Metals - urine Mothers Offspring Pregnancy Pregnancy Outcome Regression analysis Renal function Risk factors RNA-Binding Protein FUS Selenium Trace metals Zinc |
| title | Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A17%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Urinary%20metal%20profiles%20in%20mother-offspring%20pairs%20and%20their%20association%20with%20early%20dysglycemia%20in%20the%20International%20Hyperglycemia%20and%20Adverse%20Pregnancy%20Outcome%20Follow%20Up%20Study%20(HAPO-FUS)&rft.jtitle=Journal%20of%20exposure%20science%20&%20environmental%20epidemiology&rft.au=El%20Muayed,%20Malek&rft.date=2023-11-01&rft.volume=33&rft.issue=6&rft.spage=855&rft.epage=864&rft.pages=855-864&rft.issn=1559-0631&rft.eissn=1559-064X&rft_id=info:doi/10.1038/s41370-022-00511-z&rft_dat=%3Cproquest_pubme%3E2904031581%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2904031581&rft_id=info:pmid/36509832&rfr_iscdi=true |