A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis

Purpose Cisplatin resistance is the major obstacle in the clinical treatment of ovarian cancer patients. Molecular mechanisms of cisplatin resistance are multifaceted. Gold(I)-compounds, i.e. N -heterocyclic carbene-gold(I)-complexes (NHC-Au(I)) has been regarded as promising cytotoxic drug candidat...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2023-07, Vol.92 (1), p.57-69
Hauptverfasser:	König, Philipp, Zhulenko, Roman, Suparman, Eloy, Hoffmeister, Henrik, Bückreiß, Nico, Ott, Ingo, Bendas, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Auranofin - pharmacology Auranofin - therapeutic use Cancer Cancer Research Cell culture Cell cycle Cell Line, Tumor Cisplatin Cisplatin - pharmacology Critical components Cytotoxic agents Cytotoxicity Drug development Drug Resistance, Neoplasm Female Flow cytometry Gold Humans Intracellular Medicine Medicine & Public Health Molecular modelling NF-E2-Related Factor 2 Oncology Original Original Article Ovarian cancer Ovarian Neoplasms - drug therapy Pharmacology/Toxicology Prospective Studies Thioredoxin Toxicity Western blotting
Online-Zugang:	Volltext
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