Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages

Macrophages constitute important immune cell targets of the antifolate methotrexate (MTX) in autoimmune diseases, including rheumatoid arthritis. Regulation of folate/MTX metabolism remains poorly understood upon pro-inflammatory (M1-type/GM-CSF-polarized) and anti-inflammatory (M2-type/M-CSF-polari...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (11), p.9641
Hauptverfasser:	Muller, Ittai B, Lin, Marry, Jonge, Robert de, Will, Nico, López-Navarro, Baltasar, Laken, Conny van der, Struys, Eduard A, Oudejans, Cees B M, Assaraf, Yehuda G, Cloos, Jacqueline, Puig-Kröger, Amaya, Jansen, Gerrit
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alternative Splicing Analysis Annotations Arthritis Autoimmune diseases Cell cycle Chemokines DNA methylation Energy metabolism Enzymatic activity Enzyme activity Enzymes Exposure Folic acid Folic Acid - metabolism Folic Acid - pharmacology Gene Expression Genes Genetic engineering Genetic research Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Histones Humans Immune system Inflammation Macrophage colony-stimulating factor Macrophage Colony-Stimulating Factor - metabolism Macrophages Macrophages - metabolism Metabolic pathways Metabolism Methotrexate Methotrexate - metabolism Methotrexate - pharmacology Monocytes Monocytes - metabolism Peptide Synthases - genetics Physiological aspects Rheumatoid arthritis Rheumatoid factor RNA RNA Precursors - metabolism Sequence analysis Vitamin B
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