Emerging Role of DREAM in Healthy Brain and Neurological Diseases

The downstream regulatory element antagonist modulator (DREAM) is a multifunctional Ca -sensitive protein exerting a dual mechanism of action to regulate several Ca -dependent processes. Upon sumoylation, DREAM enters in nucleus where it downregulates the expression of several genes provided with a...

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Veröffentlicht in:	International journal of molecular sciences 2023-05, Vol.24 (11), p.9177
Hauptverfasser:	Molinaro, Pasquale, Sanguigno, Luca, Casamassa, Antonella, Valsecchi, Valeria, Sirabella, Rossana, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Brain Brain - metabolism Brain-derived neurotrophic factor c-Fos protein Calcium Calcium ions Cell Nucleus - metabolism Central nervous system Conserved sequence Development and progression Dynorphin Dynorphins - metabolism Enzymes Epigenetic inheritance Epigenetics Gene expression Genes Genetic transcription Homeostasis Kinases Kv Channel-Interacting Proteins - metabolism Ligands Localization Membrane proteins Na+/Ca2+ exchanger Nervous system diseases Neurological diseases Neurophysiology Neuroprotection Phosphorylation Potassium Proteins Regulatory sequences Repressor Proteins - genetics Review Signs and symptoms SUMO protein Transcription factors
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