RPA engages telomeric G-quadruplexes more effectively than CST

Abstract G-quadruplexes (G4s) are a set of stable secondary structures that form within guanine-rich regions of single-stranded nucleic acids that pose challenges for DNA maintenance. The G-rich DNA sequence at telomeres has a propensity to form G4s of various topologies. The human protein complexes...

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Veröffentlicht in:	Nucleic acids research 2023-06, Vol.51 (10), p.5073-5086
Hauptverfasser:	Olson, Conner L, Barbour, Alexandra T, Wieser, Thomas A, Wuttke, Deborah S
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - genetics DNA - metabolism DNA, Single-Stranded - genetics G-Quadruplexes Humans Molecular Biology Telomere - genetics Telomere - metabolism
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