Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis

In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased ILR2α expression. The bispecific, PD1-IL2v, is a PD-1-targeted IL-2 variant (IL2v) immunocytokine with engineered IL-2 cis-targete...

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Veröffentlicht in:	Cancer cell 2023-04, Vol.41 (5), p.950-969.e6
Hauptverfasser:	Piper, Miles, Hoen, Maureen, Darragh, Laurel B, Knitz, Michael, Nugyen, Diemmy, Gadwa, Jacob, Durini, Greta, Karakoc, Idil, Grier, Abby, Neupert, Brooke, Van Court, Benjamin, Abdelazeem, Khalid N M, Yu, Justin, Olimpo, Nicholas, Corbo, Sophia, Ross, Richard Blake, Pham, Tiffany, Joshi, Molishree, Kedl, Ross M, Saviola, Anthony, Amann, Maria, Umaña, Pablo, Codarri-Deak, Laura, Klein, Christian, D’Alessandro, Angelo, Karam, Sana D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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