All-Atom Simulations Uncover Structural and Dynamical Properties of STING Proteins in the Membrane System

Recent studies have shown that the stimulator of interferon gene (STING) protein plays a central role in the immune system by facilitating the production of type I interferons in cells. The STING signaling pathway is also a prominent activator of cancer-killing T cells that initiate a powerful adapt...

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Veröffentlicht in:	Journal of chemical information and modeling 2022-09, Vol.62 (18), p.4486-4499
Hauptverfasser:	Payne, Rachel T., Crivelli, Silvia, Watanabe, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Chemical structure Computational Biochemistry Disulfides Dynamic structural analysis Humans Immune system INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Interferon Interferon Type I Ligands Lymphocytes Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Molecular dynamics Molecular Dynamics Simulation Oligomers Protein structure Proteins Residues Signaling Simulation Stimulators
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