Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation

Aims/hypothesis Several studies have identified associations between type 2 diabetes and DNA methylation (DNAm). However, the causal role of these associations remains unclear. This study aimed to provide evidence for a causal relationship between DNAm and type 2 diabetes. Methods We used bidirectio...

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Veröffentlicht in:	Diabetologia 2023-07, Vol.66 (7), p.1247-1259
Hauptverfasser:	Juvinao-Quintero, Diana L., Sharp, Gemma C., Sanderson, Eleanor C. M., Relton, Caroline L., Elliott, Hannah R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Causality Child Cholesterol CpG islands Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism DNA methylation DNA Methylation - genetics Gene mapping Genome-wide association studies Genome-Wide Association Study Genomes High density lipoprotein Human Physiology Humans Internal Medicine Lipid metabolism Longitudinal Studies Low density lipoprotein Medicine Medicine & Public Health Metabolic Diseases Population genetics Quantitative trait loci Risk factors Single-nucleotide polymorphism
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