Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB

Studies of transcriptional initiation in different bacterial clades reveal diverse molecular mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both required to express cell division genes in Actinobacteria and are essential in notable pathogens such as . The Whi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-03, Vol.120 (11), p.e2220785120
Hauptverfasser:	Lilic, Mirjana, Holmes, Neil A, Bush, Matthew J, Marti, Alexandra K, Widdick, David A, Findlay, Kim C, Choi, Young Joo, Froom, Ruby, Koh, Steven, Buttner, Mark J, Campbell, Elizabeth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites Biological Sciences Cell activation Cell division Cell Division - genetics Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA-directed RNA polymerase DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Domains Endonuclease Gene expression Gene Expression Regulation, Bacterial Homing endonuclease Molecular modelling Mutagenesis RNA polymerase Septation Sigma Factor - genetics Sigma Factor - metabolism Sporulation Transcription activation Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription initiation
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