Longitudinal assessment of cognitive function in the APPswe/PS1dE9 mouse model of Alzheimer’s-related beta-amyloidosis

Preclinical models of Alzheimer’s disease (AD)-related cognitive decline can be useful for developing therapeutics. The current study longitudinally assessed short-term memory, using a delayed matching-to-position (DMTP) task, and attention, using a 3-choice serial reaction time (3CSRT) task, from a...

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Veröffentlicht in:	Neurobiology of aging 2023-08, Vol.128, p.85-99
Hauptverfasser:	Soto, Paul L., Young, Michael E., DiMarco, Giuliana M., George, Brianna, Melnikova, Tatiana, Savonenko, Alena V., Harris, Breanna N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - psychology Alzheimer’s disease Amyloid beta-Peptides - genetics Amyloid beta-Protein Precursor - genetics Amyloidosis Animals APPswe/PS1dE9 mice Attention Cognition Delayed matching-to-position Disease Models, Animal Memory Mice Mice, Transgenic Presenilin-1 - genetics Serial reaction time
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