LRRC75A‐AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression

We aimed to investigate potential roles of LRRC75A‐AS1 delivered by M2 macrophage exosomes in inducing cervical cancer progression. We demonstrated LRRC75A‐AS1 was highly expressed in exosomes from M2 macrophages which could be absorbed by Hela cells. M2 macrophage‐derived exosomes promoted Hela cel...

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Veröffentlicht in:	Cancer science 2023-06, Vol.114 (6), p.2634-2649
Hauptverfasser:	Sui, Hong‐Ying, Cui, Xiu‐Ying, Shi, Cai‐Xia, Yan, Zhi‐Peng, Li, Hu‐Cheng, Wang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Animals Bioinformatics Cancer therapies Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cervical cancer Exosomes Exosomes - metabolism Female Flow cytometry Gelatinase B Growth factors HeLa Cells Homeodomain Proteins - metabolism Human papillomavirus Humans Laboratory animals Leukocyte migration LRRC75A‐AS1 M2 macrophages Macrophages Macrophages - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Metastases Metastasis Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miR‐429 Nanoparticles Original Pathogens RNA, Long Noncoding - metabolism SIX1 Stat3 protein Transmission electron microscopy Tumorigenesis Uterine Cervical Neoplasms - pathology
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