Primary cilia TRP channel regulates hippocampal excitability

Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but the function of PKD2L1 in neurons is undefined. In this repor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (22), p.e2219686120-e2219686120
Hauptverfasser:	Vien, Thuy N, Ta, My C, Kimura, Louise F, Onay, Tuncer, DeCaen, Paul G
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animal models Animals Autism Autism Spectrum Disorder - metabolism Biological Sciences Brain Calcium Channels - metabolism Calcium ions Cilia Cilia - metabolism Circuits Excitability Hippocampus Hippocampus - metabolism Ion channels Kidney diseases Kidneys Localization Mice Neurons Neurons - metabolism Polycystic kidney Precipitates Receptors, Cell Surface - metabolism Seizures Transient receptor potential proteins TRPP Cation Channels - genetics TRPP Cation Channels - metabolism
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