Probing differences among Aβ oligomers with two triangular trimers derived from Aβ

The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer's disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within the multitude of oligomers and fibrils the peptide...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (22), p.e2219216120
Hauptverfasser:	Kreutzer, Adam G, Guaglianone, Gretchen, Yoo, Stan, Parrocha, Chelsea Marie T, Ruttenberg, Sarah M, Malonis, Ryan J, Tong, Karen, Lin, Yu-Fu, Nguyen, Jennifer T, Howitz, William J, Diab, Michelle N, Hamza, Imane L, Lai, Jonathan R, Wysocki, Vicki H, Nowick, James S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Alzheimer's disease Amyloid beta-Peptides - metabolism Apoptosis Assembly Biological effects Biological properties Biological Sciences Cell Membrane - metabolism Crystallography Crystallography, X-Ray Endocytosis Fibrils Humans Neurodegenerative diseases Oligomers Pathogenesis Peptide Fragments - chemistry Peptides Physical Sciences Protein Conformation Structural analysis Toxicity Trimers X-ray crystallography β-Amyloid
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